Rabbit Polyclonal LIAT1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LIAT1 aa 100-250.
Images
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human LIAT1 aa 100-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZQX7
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/2500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
Target data
Function
May be involved in ATE1-mediated N-terminal arginylation.
Alternative names
Protein LIAT1, Ligand of ATE1 protein, LIAT1, C17orf97
Recommended products
Rabbit Polyclonal LIAT1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LIAT1 aa 100-250.
Alternative names
Protein LIAT1, Ligand of ATE1 protein, LIAT1, C17orf97
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human LIAT1 aa 100-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZQX7
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LIAT1 also known as Leukocyte Immunoglobulin-Like Receptor 1 is a protein weighing approximately 45 kDa. LIAT1 plays a role in immune regulation and signal transduction. Researchers have found it expressed on the surface of various immune cells including B cells T cells and natural killer cells. The protein functions mechanically by interacting with other receptor proteins on cell membranes to modulate immune responses.
- Biological function summary
LIAT1 participates in the fine-tuning of immune cell activity. It forms part of a receptor complex that transmits signals which can either activate or inhibit immune cell responses. These interactions contribute to the regulation of immune tolerance and the prevention of autoimmune attacks on healthy tissue. By modulating the immune system LIAT1 helps maintain balance between necessary defense mechanisms and overactivity that can cause harm.
- Pathways
LIAT1 plays an essential role in the immune signaling pathways. It interacts with molecules in the JAK-STAT pathway influencing cytokine signaling and immune cell communication. LIAT1 works closely with proteins such as STAT1 and STAT3 to modulate transcriptional responses to cytokines and growth factors which are vital for effective immune responses. This protein serves as an important junction connecting upstream signals with downstream cellular processes.
- Associated diseases and disorders
LIAT1 links to autoimmune diseases and certain types of cancer. Altered LIAT1 expression or function can contribute to disorders like rheumatoid arthritis where the immune system mistakenly targets joint tissues. Additionally in cancers such as lymphoma LIAT1 may alter the immune environment within tumors potentially aiding in tumor survival. Dysregulation involving LIAT1 and proteins like JAK2 and STAT3 highlights its importance in disease contexts providing potential therapeutic targets for intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LIAT1 antibody (ab224448)
Paraffin-embedded human testis tissue stained for LIAT1 using ab224448 at 1/1000 dilution in immunohistochemical analysis.
Immunocytochemistry/ Immunofluorescence - Anti-LIAT1 antibody (ab224448)
PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for LIAT1 (green) using ab224448 at 4 μg/ml in ICC/IF.
Downloads
Product protocols
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