Rabbit Polyclonal LIFR antibody. Suitable for Flow Cyt, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Rat Lifr aa 500-550 conjugated to Keyhole Limpet Haemocyanin.
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Publications
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- Frontiers in oncology 12:9052122022Development and validation of a novel fibroblast scoring model for lung adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShiyou Wei,Xuyu Gu,Wentian ZhangPubMed 36072807
- The Journal of biological chemistry 298:1019462022Leukemia inhibitory factor protects against liver steatosis in nonalcoholic fatty liver disease patients and obese mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYouwen Yuan,Kangli Li,Fei Teng,Weiwei Wang,Bing Zhou,Xuan Zhou,Jiayang Lin,Xueru Ye,Yajuan Deng,Wenhui Liu,Shenjian Luo,Peizhen Zhang,Deying Liu,Minghua Zheng,Jin Li,Yan Lu,Huijie ZhangPubMed 35447114
- Digestive diseases and sciences 67:2244-22562021Lidocaine Suppresses Gastric Cancer Development Through Circ_ANO5/miR-21-5p/LIFR Axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEnjian Guan,Hongrong Liu,Ning XuPubMed 34050852
- Oncogene 40:791-8052020STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT-MET switch and cancer metastasis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei-Hsin Lin,Yi-Wen Chang,Min-Xiang Hong,Te-Cheng Hsu,Ko-Chuan Lee,Che Lin,Jia-Lin LeePubMed 33262462
- BioMed research international 2019:16138202019Leukemia Inhibitory Factor Receptor Is Involved in Apoptosis in Rat Astrocytes Exposed to Oxygen-Glucose Deprivation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLiang Huo et. al.PubMed 30937308
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Rat Lifr aa 500-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link O70535
Reactivity data
Select an application| Flow Cyt | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
Associated Products
Select an associated product type
5 products for Alternative Product
Target data
Function
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
Alternative names
CD118, Leukemia inhibitory factor receptor, LIF receptor, LIF-R, LIFR
Recommended products
Rabbit Polyclonal LIFR antibody. Suitable for Flow Cyt, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Rat Lifr aa 500-550 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Rat Lifr aa 500-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link O70535
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The leukemia inhibitory factor receptor also known as LIFR is a protein that plays an important role in cellular signaling. It has a mass of approximately 190-210 kDa and it is widely expressed in various tissues such as the liver muscle and bone. LIFR is a member of the interleukin 6 (IL-6) receptor family. The 'LIFR selector' refers to its ability to bind and select its specific ligand leukemia inhibitory factor (LIF) which initiates signal transduction processes. LIFR expression tends to be higher in developing tissues indicating its involvement during embryogenesis.
- Biological function summary
The leukemia inhibitory factor receptor is involved in various cellular processes including differentiation proliferation and survival. When LIF binds to LIFR it forms a complex with gp130 another receptor protein which then activates downstream signaling pathways that regulate these cellular processes. This complex formation is an important component in the maintenance of stem cell pluripotency which is important in early development. The LIFR meaning in this context is essential for translating extracellular signals into cellular responses.
- Pathways
The leukemia inhibitory factor receptor plays a critical role in the JAK/STAT signaling pathway. This pathway is significant for transmitting information received from extracellular chemical signals to the cell nucleus resulting in DNA transcription. LIFR closely interacts with other proteins like STAT3 and JAK1 which further propagate the signaling cascade initiated by LIF binding. Another pathway involving LIFR is the MAPK/ERK pathway a major pathway that influences cell growth and differentiation. These pathways highlight the interconnectivity of LIFR in regulating key cellular functions.
- Associated diseases and disorders
LIFR has been linked to cancer progression and osteoporosis. Abnormal LIFR signaling can lead to unchecked cellular proliferation contributing to tumorigenesis in various cancers such as liver and breast cancer. LIFR also interacts with proteins like gp130 and the aforementioned STAT3 in the cancerous context. In osteoporosis altered LIFR expression affects bone metabolism potentially leading to increased bone resorption and weakening. The role of LIFR in these diseases demonstrates its potential as a therapeutic target and its importance in maintaining normal tissue homeostasis.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Flow Cytometry - Anti-LIFR antibody (ab202847)
Flow Cytometry of Human U937 cells with Anti-KIBRA antibody ab216508 at 1/100
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LIFR antibody (ab202847)
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human breast carcinomal tissue labeling LIFR with ab202847 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LIFR antibody (ab202847)
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human colon carcinomal tissue labeling LIFR with ab202847 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.
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