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AB235908

Anti-LIFR antibody

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(5 Publications)

Rabbit Polyclonal LIFR antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LIFR aa 900 to C-terminus.

View Alternative Names

CD118, Leukemia inhibitory factor receptor, LIF receptor, LIF-R, LIFR

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-LIFR antibody (AB235908)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LIFR antibody (AB235908)

4% formaldehyde fixed, 0.2% Triton X-100 permeabilized HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for LIFR (green) using ab235908 at 1/200 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human LIFR aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P42702

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The leukemia inhibitory factor receptor also known as LIFR is a protein that plays an important role in cellular signaling. It has a mass of approximately 190-210 kDa and it is widely expressed in various tissues such as the liver muscle and bone. LIFR is a member of the interleukin 6 (IL-6) receptor family. The 'LIFR selector' refers to its ability to bind and select its specific ligand leukemia inhibitory factor (LIF) which initiates signal transduction processes. LIFR expression tends to be higher in developing tissues indicating its involvement during embryogenesis.
Biological function summary

The leukemia inhibitory factor receptor is involved in various cellular processes including differentiation proliferation and survival. When LIF binds to LIFR it forms a complex with gp130 another receptor protein which then activates downstream signaling pathways that regulate these cellular processes. This complex formation is an important component in the maintenance of stem cell pluripotency which is important in early development. The LIFR meaning in this context is essential for translating extracellular signals into cellular responses.

Pathways

The leukemia inhibitory factor receptor plays a critical role in the JAK/STAT signaling pathway. This pathway is significant for transmitting information received from extracellular chemical signals to the cell nucleus resulting in DNA transcription. LIFR closely interacts with other proteins like STAT3 and JAK1 which further propagate the signaling cascade initiated by LIF binding. Another pathway involving LIFR is the MAPK/ERK pathway a major pathway that influences cell growth and differentiation. These pathways highlight the interconnectivity of LIFR in regulating key cellular functions.

LIFR has been linked to cancer progression and osteoporosis. Abnormal LIFR signaling can lead to unchecked cellular proliferation contributing to tumorigenesis in various cancers such as liver and breast cancer. LIFR also interacts with proteins like gp130 and the aforementioned STAT3 in the cancerous context. In osteoporosis altered LIFR expression affects bone metabolism potentially leading to increased bone resorption and weakening. The role of LIFR in these diseases demonstrates its potential as a therapeutic target and its importance in maintaining normal tissue homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
See full target information LIFR
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cells 11: PubMed36359879

2022

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Cristina Di Giorgio,Antonio Lupia,Silvia Marchianò,Martina Bordoni,Rachele Bellini,Carmen Massa,Ginevra Urbani,Rosalinda Roselli,Federica Moraca,Valentina Sepe,Bruno Catalanotti,Elva Morretta,Maria Chiara Monti,Michele Biagioli,Eleonora Distrutti,Angela Zampella,Stefano Fiorucci

Frontiers in oncology 12:939969 PubMed35847866

2022

Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Cristina Di Giorgio,Silvia Marchianò,Elisabetta Marino,Michele Biagioli,Rosalinda Roselli,Martina Bordoni,Rachele Bellini,Ginevra Urbani,Angela Zampella,Eleonora Distrutti,Annibale Donini,Luigina Graziosi,Stefano Fiorucci

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 42:598-602 PubMed34455749

2021

[The expression and prognostic value of PD-1, TIM-3, LAG-3 and BTLA in extranodal NK/T cell lymphoma].

Applications

Unspecified application

Species

Unspecified reactive species

L Nie,X Y Liu,R J Ma,X L Yuan,L Jiang,J Yang,A X Hu,Z Li,Z M Zhu

Endocrine journal 68:1347-1357 PubMed34261825

2021

TGF-β1 induced proliferation, migration, and ECM accumulation through the SNHG11/miR-34b/LIF pathway in human pancreatic stellate cells.

Applications

Unspecified application

Species

Unspecified reactive species

Desheng Wu,Jin Guo,Benquan Qi,Heng Xiao

Environmental toxicology 36:1052-1060 PubMed33475233

2021

Hsa_circ_0001073 targets miR-626/LIFR axis to inhibit lung cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Qun Liu,Gang Cao,Yufeng Wan,Chuanqin Xu,Yuanqiang He,Gang Li
View all publications
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