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AB89792

Anti-LIFR antibody [MM0455-9B23]

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(3 Publications)

Mouse Monoclonal LIFR antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LIFR.

View Alternative Names

CD118, Leukemia inhibitory factor receptor, LIF receptor, LIF-R, LIFR

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0455-9B23

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

Flow Cyt, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LIFR.

P42702

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Alternative Products

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Complementary Products

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
IgG fraction of cell culture supernatant purified by Protein G affinity chromatography and 0.2 µm filtered.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The leukemia inhibitory factor receptor also known as LIFR is a protein that plays an important role in cellular signaling. It has a mass of approximately 190-210 kDa and it is widely expressed in various tissues such as the liver muscle and bone. LIFR is a member of the interleukin 6 (IL-6) receptor family. The 'LIFR selector' refers to its ability to bind and select its specific ligand leukemia inhibitory factor (LIF) which initiates signal transduction processes. LIFR expression tends to be higher in developing tissues indicating its involvement during embryogenesis.
Biological function summary

The leukemia inhibitory factor receptor is involved in various cellular processes including differentiation proliferation and survival. When LIF binds to LIFR it forms a complex with gp130 another receptor protein which then activates downstream signaling pathways that regulate these cellular processes. This complex formation is an important component in the maintenance of stem cell pluripotency which is important in early development. The LIFR meaning in this context is essential for translating extracellular signals into cellular responses.

Pathways

The leukemia inhibitory factor receptor plays a critical role in the JAK/STAT signaling pathway. This pathway is significant for transmitting information received from extracellular chemical signals to the cell nucleus resulting in DNA transcription. LIFR closely interacts with other proteins like STAT3 and JAK1 which further propagate the signaling cascade initiated by LIF binding. Another pathway involving LIFR is the MAPK/ERK pathway a major pathway that influences cell growth and differentiation. These pathways highlight the interconnectivity of LIFR in regulating key cellular functions.

LIFR has been linked to cancer progression and osteoporosis. Abnormal LIFR signaling can lead to unchecked cellular proliferation contributing to tumorigenesis in various cancers such as liver and breast cancer. LIFR also interacts with proteins like gp130 and the aforementioned STAT3 in the cancerous context. In osteoporosis altered LIFR expression affects bone metabolism potentially leading to increased bone resorption and weakening. The role of LIFR in these diseases demonstrates its potential as a therapeutic target and its importance in maintaining normal tissue homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
See full target information LIFR
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell 182:594-608.e11 PubMed32679030

2020

Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Huang,Aparna Bhaduri,Dmitry Velmeshev,Shaohui Wang,Li Wang,Catherine A Rottkamp,Arturo Alvarez-Buylla,David H Rowitch,Arnold R Kriegstein

Molecular medicine reports 19:4719-4726 PubMed31059010

2019

Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Wang,Ruiqiao Yan,Xiaoyuan Xu,Huan Yu,Jianfang Wu,Yaofang Yang,Weidong Li

Molecular and cellular biochemistry 449:295-303 PubMed29959592

2018

miR-377-3p regulates adipogenic differentiation of human bone marrow mesenchymal stem cells by regulating LIFR.

Applications

Unspecified application

Species

Unspecified reactive species

Xingnuan Li,Yaofang Yang,Ruiqiao Yan,Xiaoyuan Xu,Liyun Gao,Jun Mei,Jianyun Liu,Xinping Wang,Jie Zhang,Ping Wu,Weidong Li,Zhijun Zhao,Jianjun Xiong,Tao Wang
View all publications
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Product promise

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