Anti-LIMCH1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The LIM and Calponin Homology Domain 1 known as LIMCH1 is a protein with a mass of approximately 90 kDa. It functions mechanically by interacting with actin filaments influencing their organization and stability. LIMCH1 contains a LIM domain which provides a scaffold for protein-protein interactions and a calponin homology domain which binds actin. LIMCH1 is expressed in various tissues including skeletal muscle heart and brain indicating its involvement in multiple cellular functions.

Biological function summary

LIMCH1 modulates cytoskeletal dynamics and plays a role in cell shape and motility. It forms part of protein complexes that regulate the architecture of the actin cytoskeleton. These complexes involve other actin-binding proteins contributing to processes like cell adhesion and migration. LIMCH1 influences the remodeling of cytoskeletal structures critical for cellular responses to environmental changes and mechanical stress.

Pathways

Researchers identify LIMCH1 as a component in the RhoA signaling pathway which controls actin cytoskeleton dynamics. LIMCH1 interacts with proteins like Rho-associated protein kinase (ROCK) and myosin light chain kinase (MLCK) coordinating actomyosin contractility. Another significant pathway involving LIMCH1 is the regulation of focal adhesion where it associates with vinculin and talin contributing to the linkage between the plasma membrane and the cytoskeletal framework.

Associated diseases and disorders

Abnormalities in LIMCH1 expression or function relate to conditions such as heart hypertrophy and certain types of cancer. In cardiac muscle cells disrupted LIMCH1 activity can lead to altered contractility linking it to heart disease. Furthermore in the context of cancer LIMCH1's modulation of cell migration and adhesion connects it to metastasis. Studies also find its interactions with proteins like p53 a well-known tumor suppressor as important in these disease processes.