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AB71887

Anti-LIN9/TGS antibody

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(1 Publication)

Mouse Polyclonal LIN9/TGS antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LIN9.

View Alternative Names

BARA, TGS, LIN9, Protein lin-9 homolog, HuLin-9, hLin-9, Beta subunit-associated regulator of apoptosis, TUDOR gene similar protein, Type I interferon receptor beta chain-associated protein, pRB-associated protein

1 Images
Western blot - Anti-LIN9/TGS antibody (AB71887)
  • WB

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Western blot - Anti-LIN9/TGS antibody (AB71887)

All lanes:

Western blot - Anti-LIN9/TGS antibody (ab71887) at 1/500 dilution

Lane 1:

LIN9/TGS transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat anti-mouse (H&L)-HRP conjugate at 1/2500 dilution

Predicted band size: 62 kDa

Observed band size: 75 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LIN9.

Q5TKA1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LIN9 also known as TGS is a component of the multiprotein MuvB complex integral to cell cycle regulation. The protein has an approximate mass of 73 kDa and shows expression in various tissues with higher levels seen in proliferative cells. LIN9 plays a significant role in transcriptional activation particularly during the G1/S and G2/M transitions of the cell cycle. Its expression patterns suggest an important role in dividing cells.
Biological function summary

The MuvB complex where LIN9 is a part regulates genes essential for the mitotic processes. LIN9 participates in the switching of E2F target genes necessary for cell cycle entry and progression. It aids in chromatin remodeling facilitating the transcription of genes needed for DNA replication and chromosome segregation. This role places LIN9 at the heart of many cellular proliferation processes.

Pathways

Cell cycle control represents one of the core pathways involving LIN9. This protein connects with the Retinoblastoma (Rb) pathway interacting with proteins like E2F4 and p130. These interactions reflect LIN9's important role in the regulation of cell cycle genes and checkpoints helping to ensure proper DNA replication and mitosis. LIN9 also engages with other pathways such as the DNA damage response highlighting its broader impact on genomic stability.

LIN9’s misregulation associates with cancer and various proliferative disorders. In cancers alterations in LIN9 expression can lead to uncontrolled cell cycle progression contributing to tumorigenesis. Dysregulation also connects LIN9 to neurodegenerative disorders. LIN9's interaction with proteins like E2F4 establishes a link with retinoblastoma susceptibility highlighting its potential role in both neoplastic and non-neoplastic disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.
See full target information LIN9
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Genome biology 16:130 PubMed26100407

2015

FOXM1 binds directly to non-consensus sequences in the human genome.

Applications

IP

Species

Human

Deborah A Sanders,Michael V Gormally,Giovanni Marsico,Dario Beraldi,David Tannahill,Shankar Balasubramanian
View all publications
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