JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB90573

Anti-LIP1 antibody

5

(2 Reviews)

|

(1 Publication)

Rabbit Polyclonal LIP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human STK11IP aa 900-950.

View Alternative Names

KIAA1898, LIP1, LKB1IP, STK11IP1, STK11IP, Serine/threonine-protein kinase 11-interacting protein, LKB1-interacting protein 1

2 Images
Immunoprecipitation - Anti-LIP1 antibody (AB90573)
  • IP

Unknown

Immunoprecipitation - Anti-LIP1 antibody (AB90573)

ab90573 at 1 µg/ml detecting LIP1 following immunoprecipitation.

Lane 1; IP HeLa (Human cervix adenocarcinoma epithelial cell) whole cell lysate using ab90573

Lane 2; IP HeLa whole cell lysate using an antibody to an upstream epitope of LIP1

Lane 3; IP using control IgG

All antibodies used at 3 µg/mg lysate. 1 mg of lysate precipitated and 20% loaded.

Developed using the ECL technique with a 30 second exposure.

All lanes:

Immunoprecipitation - Anti-LIP1 antibody (ab90573)

Predicted band size: 121 kDa

false

Western blot - Anti-LIP1 antibody (AB90573)
  • WB

Unknown

Western blot - Anti-LIP1 antibody (AB90573)

All lanes:

Western blot - Anti-LIP1 antibody (ab90573) at 0.4 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

HeLa whole cell lysate at 5 µg

Predicted band size: 121 kDa

true

Exposure time: 30s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP, WB

applications

Immunogen

Synthetic Peptide within Human STK11IP aa 900-950. The exact immunogen used to generate this antibody is proprietary information.

Q8N1F8

style
left-column

Complementary Products

Primary Antibodies

AB176689

Anti-ZNF384 antibody

Immunoprecipitation - Anti-ZNF384 antibody (AB176689)

  • 5
  • 1
Primary Antibodies

AB14734

Anti-VDAC1/Porin + VDAC3 antibody [20B12AF2] - Mitochondrial Loading Control

Recombinant|Lab Essentials

Western blot - Anti-VDAC1/Porin + VDAC3 antibody [20B12AF2] - Mitochondrial Loading Control (AB14734)

  • 5
  • 52
Primary Antibodies

AB110330

Anti-PDHA1 antibody [9H9AF5]

KO Validated

Western blot - Anti-PDHA1 antibody [9H9AF5] (AB110330)

  • 5
  • 8
Primary Antibodies

AB181152

Anti-ZCCHC8 antibody [EPR13612]

RabMAb|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-ZCCHC8 antibody [EPR13612] (AB181152)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Baboon": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LIP1 also known as Lipone is a mechanistic protein involved in cellular lipid metabolism. It has an approximate molecular mass of 60 kDa and is highly expressed in liver and adipose tissues in humans. Its role includes acting as an enzyme responsible for catalyzing the breakdown of lipids within cells. By participating in these processes LIP1 facilitates the regulation of lipid homeostasis impacting the availability of fatty acids and glycerol for cellular energy needs.
Biological function summary

LIP1 plays an important role in the cellular lipid degradation process. It functions as part of a multiprotein complex that includes lipid transporters and other metabolic enzymes. This involvement allows the protein to manage lipid turnover and maintain balance within cellular environments. Within cells LIP1 modulates lipid storage and release adapting these processes in response to cellular energy status and nutrient availability.

Pathways

LIP1 contributes significantly to the fatty acid oxidation and lipolysis pathways. In these pathways LIP1 interacts with proteins such as hormone-sensitive lipase and adipose triglyceride lipase aiding in the effective breakdown and utilization of stored triglycerides. These pathways not only contribute to cellular energy production but also influence metabolic rate and energy expenditure at the organism level.

LIP1 is connected to metabolic conditions such as obesity and type 2 diabetes. Its dysfunction can lead to impaired lipid metabolism and excessive lipid accumulation contributing to these metabolic disorders. Additionally LIP1 has been studied in relation to its interactions with proteins like peroxisome proliferator-activated receptor gamma which plays roles both in lipid metabolism and in the pathophysiology of these conditions. Understanding LIP1's activities offers potential therapeutic targets for metabolic diseases treatment.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May regulate STK11/LKB1 function by controlling its subcellular localization.
See full target information STK11IP
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 39:101-112 PubMed27959388

2016

A tryptophan derivative, ITE, enhances liver cell metabolic functions in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoqian Zhang,Juan Lu,Bin He,Lingling Tang,Xiaoli Liu,Danhua Zhu,Hongcui Cao,Yingjie Wang,Lanjuan Li
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com