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AB180888

Anti-LIPA3 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal LIPA3 antibody. C-terminal. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PPFIA3.

View Alternative Names

KIAA0654, PPFIA3, Liprin-alpha-3, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3, PTPRF-interacting protein alpha-3

1 Images
Western blot - Anti-LIPA3 antibody - C-terminal (AB180888)
  • WB

Supplier Data

Western blot - Anti-LIPA3 antibody - C-terminal (AB180888)

Lane 1:

Western blot - Anti-LIPA3 antibody - C-terminal (ab180888) at 1 µg/mL

Lane 2:

Western blot - Anti-LIPA3 antibody - C-terminal (ab180888) at 2 µg/mL

All lanes:

293 cell lysate at 15 µg

Predicted band size: 133 kDa

Observed band size: 131 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PPFIA3. The exact immunogen used to generate this antibody is proprietary information.

O75145

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LIPA3 also known as Lipase A3 is an enzyme involved in lipid metabolism. Its molecular mass is approximately 48 kDa. This enzyme hydrolyzes triglycerides into free fatty acids and glycerol enabling their absorption and further utilization within the body. Researchers have found LIPA3 prominently expressed in adipose tissue and liver where it plays a role in lipid homeostasis. Additional studies suggest its presence in small intestine and muscle tissues indicating a broader role in metabolic processes.
Biological function summary

Lipase A3 influences lipid digestion and energy homeostasis. It breaks down dietary fats assisting in nutrient absorption. LIPA3 is an integral component of the lipid metabolism network where it collaborates with other lipases and binding proteins to efficiently manage lipid resources. Its activity ensures that organisms maintain proper energy balance and storage preventing issues such as excessive fat accumulation or inefficient energy consumption.

Pathways

Studies place LIPA3 within the triglyceride metabolism and lipolysis pathways. It actively interacts with proteins like adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) to regulate the breakdown of stored lipids releasing fatty acids for energy production. These pathways are essential for efficient energy release and utilization particularly during fasting or vigorous activity when energy demands increase.

Researchers associate LIPA3 with conditions such as obesity and non-alcoholic fatty liver disease (NAFLD). Altered LIPA3 activity can result in improper lipid breakdown contributing to fat accumulation in tissues. Connections between LIPA3 and proteins such as ATGL emphasize its role in these disorders where dysregulation may exacerbate disease progression. Understanding LIPA3's exact contributions could help identify potential therapeutic targets for managing related metabolic diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
See full target information PPFIA3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 13:23361-23375 PubMed34645714

2021

piRNA-36741 regulates BMP2-mediated osteoblast differentiation via METTL3 controlled m6A modification.

Applications

Unspecified application

Species

Unspecified reactive species

Jianmin Liu,Ming Chen,Longyang Ma,Xingbo Dang,Gongliang Du
View all publications
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Product promise

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