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AB215843

Anti-Liver Arginase antibody [ARG1/1125]

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(2 Publications)

Mouse Monoclonal Liver Arginase antibody. Suitable for WB, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARG1 aa 1-150.

View Alternative Names

Arginase-1, Liver-type arginase, Type I arginase, ARG1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [ARG1/1125] (AB215843)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [ARG1/1125] (AB215843)

Immunohistochemical analysis of formalix-fixed paraffin-embedded Human hepatocellular carcinoma tissue, labeling Liver Arginase using ab215843 at 4 μg/mL.

Protein Array - Anti-Liver Arginase antibody [ARG1/1125] (AB215843)
  • Protein Array

Unknown

Protein Array - Anti-Liver Arginase antibody [ARG1/1125] (AB215843)

ab215843 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Western blot - Anti-Liver Arginase antibody [ARG1/1125] (AB215843)
  • WB

Supplier Data

Western blot - Anti-Liver Arginase antibody [ARG1/1125] (AB215843)

All lanes:

Western blot - Anti-Liver Arginase antibody [ARG1/1125] (ab215843) at 1 µg/mL

Lane 1:

recombinant Human Liver Arginase protein fragment

Lane 2:

Human liver lysate

Predicted band size: 35 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

ARG1/1125

Isotype

IgG3

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

Protein Array, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ARG1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

P05089

Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed : 15546957, PubMed : 16709924, PubMed : 19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.
See full target information ARG1

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Drug development research 85:e22230 PubMed38967729

2024

Inhibition of the TCF12/VSIG4 axis by palbociclib diminishes the proliferation and migration of glioma cells and decreases the M2 polarization of glioma-associated microglia.

Applications

Unspecified application

Species

Unspecified reactive species

Chuankun Li,Ruichun Li,Yuan Wang,Haitao Jiang

Oxidative medicine and cellular longevity 2022:8983667 PubMed35847582

2022

Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying circ_0050205 Attenuate Intervertebral Disc Degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Jun Yu,Qi-Kun Liu,Rui Lu,Shan-Xi Wang,Hao-Ran Xu,Ying-Guang Wang,Yuan Bao,Yong-Qiao Jiang,Meng-Wei Li,Hao Kang
View all publications

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