Mouse Monoclonal Liver Arginase antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Pig, Human samples. Cited in 13 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ARG1.
Images
![Western blot - Anti-Liver Arginase antibody [C5] (AB239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--western-blot-img159371.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Liver Arginase antibody [C5] (AB239731)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [C1] (AB239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img113795.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [C1] (AB239731)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [C1] (AB239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img103229.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [C1] (AB239731)")
![Western blot - Anti-Liver Arginase antibody [C1] (AB239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--western-blot-img156561.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Liver Arginase antibody [C1] (AB239731)")
![Western blot - Anti-Liver Arginase antibody [C1] (AB239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--western-blot-img163770.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Liver Arginase antibody [C1] (AB239731)")
Publications
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- Immunity, inflammation and disease 11:e9002023Melatonin regulates microglial polarization to M2 cell via RhoA/ROCK signaling pathway in epilepsy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPingping Li,Xuefei Ji,Ming Shan,Yi Wang,Xingliang Dai,Mengyuan Yin,Yunlong Liu,Liao Guan,Lei Ye,Hongwei ChengPubMed 37382264
- Heliyon 9:e173142023Plexin D1 mediates disturbed flow-induced M1 macrophage polarization in atherosclerosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSuhui Zhang,Yingqian Zhang,Peng Zhang,Zechen Wei,Mingrui Ma,Wei Wang,Wei Tong,Feng Tian,Hui Hui,Jie Tian,Yundai ChenPubMed 37389065
- Cells 11:2022Abrocitinib Attenuates Microglia-Mediated Neuroinflammation after Traumatic Brain Injury via Inhibiting the JAK1/STAT1/NF-κB Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTuo Li,Lei Li,Ruilong Peng,Hongying Hao,Hejun Zhang,Yalong Gao,Cong Wang,Fanjian Li,Xilei Liu,Fanglian Chen,Shu Zhang,Jianning ZhangPubMed 36429017
- Frontiers in bioengineering and biotechnology 10:9593242022Therapy of spinal cord injury by folic acid polyethylene glycol amine-modified zeolitic imidazole framework-8 nanoparticles targeted activated M/Ms.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQi Li,Yue Guo,Chang Xu,Jiachen Sun,Fanzhuo Zeng,Sen Lin,Yajiang YuanPubMed 36185443
- Frontiers in pharmacology 13:8994692022Zoledronic Acid Targeting of the Mevalonate Pathway Causes Reduced Cell Recruitment and Attenuates Pulmonary Fibrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLloyd Tanner,Jesper Bergwik,Andrew B Single,Ravi K V Bhongir,Jonas S Erjefält,Arne EgestenPubMed 35721132
- Frontiers in cell and developmental biology 9:7509482021Three-Dimensionally Printed Ti2448 With Low Stiffness Enhanced Angiogenesis and Osteogenesis by Regulating Macrophage Polarization Piezo1/YAP Signaling Axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhen Tang,Xinghui Wei,Tian Li,Hao Wu,Xin Xiao,Yulin Hao,Shujun Li,Wentao Hou,Lei Shi,Xiaokang Li,Zheng GuoPubMed 34869337
- Proteomics. Clinical applications 16:e21000532021Screening of differentially expressed proteins in placentas from patients with late-onset preeclampsia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndong He,Jingyun Wang,Xiaofeng Yang,Jia Liu,Xuesong Yang,Guang Wang,Ruiman LiPubMed 34704665
- Biomedicines 9:2021Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexey Fayzullin,Semyon Churbanov,Natalia Ignatieva,Olga Zakharkina,Mark Tokarev,Daniil Mudryak,Yana Khristidis,Maxim Balyasin,Alexandr Kurkov,Elena N Golubeva,Nadejda A Aksenova,Tatyana Dyuzheva,Peter Timashev,Anna Guller,Anatoly ShekhterPubMed 34440057
- Journal of hepatocellular carcinoma 8:599-6112021Blocking the CCL5-CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuan Zhuang,Xiaomei Zhao,Baoying Yuan,Zhaochong Zeng,Yixing ChenPubMed 34178876
- Theranostics 11:6847-68592021Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing Xun,Lingfang Du,Ruifang Gao,Long Shen,Dekun Wang,Lichun Kang,Chuan'ai Chen,Zhujun Zhang,Yuying Zhang,Shijing Yue,Shuxin Feng,Rong Xiang,Xue Mi,Xiaoyue TanPubMed 34093857
Key facts
- Isotype
IgG2b
- Host species
Mouse
- Storage buffer
pH: 7.4
Preservative: 0.011% Proclin 300
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS- Form
Liquid
- Clonality
Monoclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human ARG1. Database link P05089
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Mouse | Tested | Expected | Expected |
| Pig | Tested | Expected | Expected |
| Rabbit | Predicted | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 0.50000-5.00000 µg/mL | Notes - |
Species Pig | Dilution info 0.50000-5.00000 µg/mL | Notes - |
Species Human | Dilution info 0.50000-5.00000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rabbit | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5.00000-30.00000 µg/mL | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Pig | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rabbit | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5.00000-30.00000 µg/mL | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Pig | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rabbit | Dilution info - | Notes - |
Associated Products
Select an associated product type
9 products for Alternative Product
Target data
Function
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.
Alternative names
Arginase-1, Liver-type arginase, Type I arginase, ARG1
Recommended products
Mouse Monoclonal Liver Arginase antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Pig, Human samples. Cited in 13 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ARG1.
Key facts
- Isotype
IgG2b
- Host species
Mouse
- Storage buffer
pH: 7.4
Preservative: 0.011% Proclin 300
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS- Form
Liquid
- Clonality
Monoclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human ARG1. Database link P05089
- Clone number
C5
- Purification technique
Affinity purification Protein A/G
- Light chain type
kappa
- Concentration
- Purification notes
Purified from TCS.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
8 product images
![Western blot - Anti-Liver Arginase antibody [C5] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--western-blot-img159371.jpg "Western blot - Anti-Liver Arginase antibody [C5] (ab239731)")
Western blot - Anti-Liver Arginase antibody [C5] (ab239731)
All lanes: Western blot - Anti-Liver Arginase antibody [C5] (ab239731) at 2 µg/mL
All lanes: Human liver lysate
SecondaryAll lanes: HRP-Linked goat anti-Mouse IgG at 0.2 µg/mL
Predicted band size: 35 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [C1] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img113795.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [C1] (ab239731)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [C1] (ab239731)
Paraffin-embedded human liver tissue stained for Liver Arginase using ab239731 at 20 μg/ml in immunohistochemical analysis. DAB staining. HRP-linked Goat anti-Mouse IgG was used as the secondary antibody at 2 μg/ml.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [C1] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img103229.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [C1] (ab239731)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [C1] (ab239731)
Paraffin-embedded human liver cancer tissue stained for Liver Arginase using ab239731 at 20 μg/ml in immunohistochemical analysis. DAB staining. HRP-linked Goat anti-Mouse IgG was used as the secondary antibody at 2 μg/ml.
![Western blot - Anti-Liver Arginase antibody [C1] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--western-blot-img156561.jpg "Western blot - Anti-Liver Arginase antibody [C1] (ab239731)")
Western blot - Anti-Liver Arginase antibody [C1] (ab239731)
All lanes: Western blot - Anti-Liver Arginase antibody [C1] (ab239731) at 2 µg/mL
All lanes: Pig liver lysate
SecondaryAll lanes: HRP-Linked Goat anti-Mouse IgG at 0.2 µg/mL
Predicted band size: 35 kDa
![Western blot - Anti-Liver Arginase antibody [C1] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--western-blot-img163770.jpg "Western blot - Anti-Liver Arginase antibody [C1] (ab239731)")
Western blot - Anti-Liver Arginase antibody [C1] (ab239731)
All lanes: Western blot - Anti-Liver Arginase antibody [C1] (ab239731) at 2 µg/mL
All lanes: Mouse liver lysate
SecondaryAll lanes: HRP-Linked Goat anti-Mouse IgG at 0.2 µg/mL
Predicted band size: 35 kDa
![Western blot - Anti-Liver Arginase antibody [C1] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--western-blot-img142436.jpg "Western blot - Anti-Liver Arginase antibody [C1] (ab239731)")
Western blot - Anti-Liver Arginase antibody [C1] (ab239731)
All lanes: Western blot - Anti-Liver Arginase antibody [C1] (ab239731) at 2 µg/mL
All lanes: HepG2 (human liver hepatocellular carcinoma cell line) cell lysate
SecondaryAll lanes: HRP-Linked goat anti-Mouse IgG at 0.2 µg/mL
Predicted band size: 35 kDa
![Immunocytochemistry/ Immunofluorescence - Anti-Liver Arginase antibody [C1] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--immunocytochemistry-immunofluorescence-img79610.jpg "Immunocytochemistry/ Immunofluorescence - Anti-Liver Arginase antibody [C1] (ab239731)")
Immunocytochemistry/ Immunofluorescence - Anti-Liver Arginase antibody [C1] (ab239731)
HepG2 (human liver hepatocellular carcinoma cell line) cells stained for Liver Arginase using ab239731 at 40 μg/ml in ICC/IF, followed by FITC staining.
![Western blot - Anti-Liver Arginase antibody [C5] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--western-blot-img24808.jpg "Western blot - Anti-Liver Arginase antibody [C5] (ab239731)")
Western blot - Anti-Liver Arginase antibody [C5] (ab239731)
All lanes: Western blot - Anti-Liver Arginase antibody [C5] (ab239731) at 5 µg/mL
All lanes: Recombinant human Liver Arginase protein
Predicted band size: 35 kDa
![Western blot - Anti-Liver Arginase antibody [C1] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--western-blot-img142436.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Liver Arginase antibody [C1] (ab239731)")
![Immunocytochemistry/ Immunofluorescence - Anti-Liver Arginase antibody [C1] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--immunocytochemistry-immunofluorescence-img79610.jpg/_jcr_content/renditions/webp-475.webp "Immunocytochemistry/ Immunofluorescence - Anti-Liver Arginase antibody [C1] (ab239731)")
![Western blot - Anti-Liver Arginase antibody [C5] (ab239731), expandable thumbnail](https://content.abcam.com/products/images/liver-arginase-antibody-c5-ab239731--western-blot-img24808.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Liver Arginase antibody [C5] (ab239731)")
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