AB227798

Anti-Liver Arginase antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal Liver Arginase antibody. N-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Arginase-1, Liver-type arginase, Type I arginase, ARG1

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody - N-terminal (AB227798)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody - N-terminal (AB227798)

Formalin-fixed, paraffin-embedded human hepatocellular carcinoma tissue stained for Liver Arginase using ab227798 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody - N-terminal (AB227798)

Formalin-fixed, paraffin-embedded human liver tissue stained for Liver Arginase using ab227798 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-Liver Arginase antibody - N-terminal (AB227798)

All lanes:

Western blot - Anti-Liver Arginase antibody - N-terminal (ab227798) at 1/100 dilution

All lanes:

MOLT-4 (human lymphoblastic leukemia cell line) cell lysate

Predicted band size: 35 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.6 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed : 15546957, PubMed : 16709924, PubMed : 19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.

See full target information ARG1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:3220 PubMed38622115

2024

Reciprocal antagonism of PIN1-APC/C governs mitotic protein stability and cell cycle entry.

Applications

Unspecified application

Species

Unspecified reactive species

Shizhong Ke,Fabin Dang,Lin Wang,Jia-Yun Chen,Mandar T Naik,Wenxue Li,Abhishek Thavamani,Nami Kim,Nandita M Naik,Huaxiu Sui,Wei Tang,Chenxi Qiu,Kazuhiro Koikawa,Felipe Batalini,Emily Stern Gatof,Daniela Arango Isaza,Jaymin M Patel,Xiaodong Wang,John G Clohessy,Yujing J Heng,Galit Lahav,Yansheng Liu,Nathanael S Gray,Xiao Zhen Zhou,Wenyi Wei,Gerburg M Wulf,Kun Ping Lu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Liver Arginase antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody - N-terminal (AB227798)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody - N-terminal (AB227798)

Western blot - Anti-Liver Arginase antibody - N-terminal (AB227798)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (1)

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