Rabbit Polyclonal Livin antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BIRC7 aa 1-250.
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Publications
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- Journal of Cancer 12:467-4732021MUC 15 Promotes Osteosarcoma Cell Proliferation, Migration and Invasion through Livin, MMP-2/MMP-9 and Wnt/β-Catenin Signal Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTonglei Chen et. al.PubMed 33391443
- Aging 12:2020High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCheng-Yu Jin et. al.PubMed 33411689
- Neoplasma 67:102-1102019MiR-512-3p regulates malignant tumor behavior and multi-drug resistance in breast cancer cells via targeting Livin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesW J Duan,P D Bi,Y Ma,N Q Liu,X ZhenPubMed 31777256
- American journal of physiology. Lung cellular and molecular physiology 316:L918-L9332019Tumor-suppressive effects of microRNA-181d-5p on non-small-cell lung cancer through the CDKN3-mediated Akt signaling pathway in vivo and in vitro.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi-Ming Gao,Yue Zheng,Ping Wang,Lei Zheng,Wen-Li Zhang,Ya Di,Lan-Lan Chen,Xiao-Bo Yin,Qi Tian,Shan-Shan Shi,Shu-Feng XuPubMed 30628487
- Journal of cellular physiology 234:433-4422018Effects of RNA interference-mediated silencing of toll-like receptor 4 gene on proliferation and apoptosis of human breast cancer MCF-7 and MDA-MB-231 cells: An in vitro study.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiao-Ling Gao et. al.PubMed 29932226
- Oncology letters 15:7707-77152018Silencing Livin improved the sensitivity of colon cancer cells to 5-fluorouracil by regulating crosstalk between apoptosis and autophagy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShuai Liu et. al.PubMed 29740490
- Oncology letters 14:7759-77662017Livin serves as a prognostic marker for mid-distal rectal cancer and a target of mid-distal rectal cancer treatment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQi-Biao Su et. al.PubMed 29344221
- International journal of oncology 43:159-682013RNA interference-mediated knockdown of Livin suppresses cell proliferation and invasion and enhances the chemosensitivity to cisplatin in human osteosarcoma cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXu Li et. al.PubMed 23632777
- Pigment cell & melanoma research 26:377-912013BRG1 promotes survival of UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene.Applications:WBReactive species:Unspecified reactive speciesSrinivas V Saladi et. al.PubMed 23480510
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human BIRC7 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q96CA5
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/200.00000 | Notes - |
Target data
Function
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed:11024045, PubMed:11084335, PubMed:11162435, PubMed:16729033, PubMed:17294084). Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity (PubMed:11024045, PubMed:16729033). As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival (PubMed:16729033). May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions (PubMed:16729033). Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine (PubMed:11084335, PubMed:11162435, PubMed:11865055). Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2 (PubMed:11865055). This activation depends on TAB1 and MAP3K7/TAK1 (PubMed:11865055). In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9 (PubMed:11024045). Isoform 1. Blocks staurosporine-induced apoptosis (PubMed:11322947). Promotes natural killer (NK) cell-mediated killing (PubMed:18034418). Isoform 2. Blocks etoposide-induced apoptosis (PubMed:11162435, PubMed:11322947). Protects against natural killer (NK) cell-mediated killing (PubMed:18034418).
Alternative names
KIAP, LIVIN, MLIAP, RNF50, UNQ5800/PRO19607/PRO21344, BIRC7, Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, Livin, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RING-type E3 ubiquitin transferase BIRC7, ML-IAP
Recommended products
Rabbit Polyclonal Livin antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BIRC7 aa 1-250.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human BIRC7 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q96CA5
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
Western blot - Anti-Livin antibody (ab97350)
12% SDS PAGE
All lanes: Western blot - Anti-Livin antibody (ab97350) at 1/1000 dilution
All lanes: A431 whole cell lysate at 30 µg
Predicted band size: 33 kDa
Immunocytochemistry/ Immunofluorescence - Anti-Livin antibody (ab97350)
ab97350, at a 1/200 dilution, staining Livin in paraformaldehyde fixed HeLa cell by immunofluorescence.
The lower image shows ab97350 merged with DNA probe.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Livin antibody (ab97350)
ab97350, at a 1/100 dilution, staining Livin in paraffin embedded Cal27 xenograft by Immunohistochemistry.
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