Anti-Livin antibody

Target data

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed : 11024045, PubMed : 11084335, PubMed : 11162435, PubMed : 16729033, PubMed : 17294084). Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity (PubMed : 11024045, PubMed : 16729033). As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival (PubMed : 16729033). May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions (PubMed : 16729033). Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine (PubMed : 11084335, PubMed : 11162435, PubMed : 11865055). Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2 (PubMed : 11865055). This activation depends on TAB1 and MAP3K7/TAK1 (PubMed : 11865055). In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9 (PubMed : 11024045).. Isoform 1. Blocks staurosporine-induced apoptosis (PubMed : 11322947). Promotes natural killer (NK) cell-mediated killing (PubMed : 18034418).. Isoform 2. Blocks etoposide-induced apoptosis (PubMed : 11162435, PubMed : 11322947). Protects against natural killer (NK) cell-mediated killing (PubMed : 18034418).