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AB235524

Anti-LIX1 antibody

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(1 Publication)

Rabbit Polyclonal LIX1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LIX1.

View Alternative Names

C5orf11, LIX1, Protein limb expression 1 homolog

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LIX1 antibody (AB235524)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LIX1 antibody (AB235524)

Paraffin-embedded human placenta tissue stained for LIX1 using ab235524 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-LIX1 antibody (AB235524)
  • WB

Supplier Data

Western blot - Anti-LIX1 antibody (AB235524)

All lanes:

Western blot - Anti-LIX1 antibody (ab235524) at 1/500 dilution

All lanes:

Mouse heart tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 31 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LIX1.

Q8N485

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LIX1 also known as Limb and CNS Expressed 1 represents a protein with a mass of approximately 18 kDa. It expresses primarily in the central nervous system and limb tissues. This protein exhibits particular importance in developmental processes. Structural studies reveal that LIX1 may play a role in molecular signaling involving interactions with other intracellular proteins to facilitate its function.
Biological function summary

LIX1 supports the regulation of cell proliferation and differentiation particularly during early embryonic development. Evidence suggests that it may interact with cellular scaffolding proteins supporting its integration into larger protein complexes. LIX1 ensures the precision of cellular growth and structural development acting as a potential modulator of morphogenetic signals.

Pathways

Studies suggest that LIX1 participates in the Wnt signaling pathway and the Hedgehog signaling pathway. These pathways are fundamental in the regulation of developmental processes such as tissue patterning and cell fate determination. LIX1's involvement with these pathways aligns it closely with other proteins like β-catenin in the Wnt pathway and GLI family proteins in the Hedgehog pathway facilitating finely tuned biological responses.

Research has connected LIX1 with colorectal cancer and limb development disorders. Altered expression or dysfunction of LIX1 may contribute to improper cellular growth regulation thereby affecting these conditions. In the context of limb development disorders LIX1 may work in conjunction with other proteins such as Sonic Hedgehog (SHH) important for the proper formation of limb structures. Understanding LIX1's role in these diseases could help further identify therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information LIX1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 12:5035-5054 PubMed36205357

2022

Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance.

Applications

Unspecified application

Species

Unspecified reactive species

Min Tang,Juan Chen,Tian Zeng,Dong-Mei Ye,Yu-Kun Li,Juan Zou,Yu-Ping Zhang
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Product promise

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