AB220622

Anti-LLPH antibody

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(1 Publication)

Rabbit Polyclonal LLPH antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LLPH aa 50 to C-terminus.

View Alternative Names

C12orf31, cPERP-G, LLPH, Protein LLP homolog, Protein LAPS18-like

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-LLPH antibody (AB220622)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LLPH antibody (AB220622)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized MCF7 cells labeling LLPH with ab220622 at 4 μg/mL (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human LLPH aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BRT6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LLPH also known as L-Lactate Dehydrogenase A-like Protein plays a significant role in cellular metabolism by facilitating the conversion of lactate to pyruvate and back which is important for anaerobic and aerobic energy production. LLPH is approximately 42 kDa in mass. Expression of LLPH occurs in a variety of tissues including the brain liver and heart suggesting its involvement in numerous physiological processes.

Biological function summary

LLPH influences energy metabolism and cell proliferation by modulating the balance between lactate and pyruvate. LLPH functions independently and doesn't form part of any larger protein complex. Its role ensures efficient energy use within the cell making it vital for maintaining cellular homeostasis under varying oxygen conditions.

Pathways

LLPH contributes significantly to glycolysis and gluconeogenesis aiding the cellular response to changes in energy demand. It interrelates with enzymes such as pyruvate dehydrogenase which further integrate these pathways into central energy metabolism maintaining the cell’s energy equilibrium under different environmental and physiological conditions.

Changes in LLPH expression levels and activity have connections to cancer and metabolic disorders. In cancer aberrant LLPH expression often correlates with increased tumor growth and survival. It associates with oncogenes like Myc which influence cancer cell metabolism by regulating the expression of metabolic enzymes including LLPH.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.

See full target information LLPH

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 11:2977 PubMed32532995

2020

A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Siobhan S Pattwell,Sonali Arora,Patrick J Cimino,Tatsuya Ozawa,Frank Szulzewsky,Pia Hoellerbauer,Tobias Bonifert,Benjamin G Hoffstrom,Norman E Boiani,Hamid Bolouri,Colin E Correnti,Barbara Oldrini,John R Silber,Massimo Squatrito,Patrick J Paddison,Eric C Holland

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-LLPH antibody

Immunocytochemistry/ Immunofluorescence - Anti-LLPH antibody (AB220622)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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