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AB105419

Anti-LMBRD1 antibody

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(1 Publication)

Rabbit Polyclonal LMBRD1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LMBRD1.

View Alternative Names

C6orf209, NESI, BM-021, CD001, MSTP044, LMBRD1, Lysosomal cobalamin transport escort protein LMBD1, LMBD1, HDAg-L-interacting protein NESI, LMBR1 domain-containing protein 1, Nuclear export signal-interacting protein

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-LMBRD1 antibody (AB105419)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-LMBRD1 antibody (AB105419)

Immunofluorescence of LMBRD1 in Human brain tissue with ab105419 at 20 ug/mL.

Western blot - Anti-LMBRD1 antibody (AB105419)
  • WB

Unknown

Western blot - Anti-LMBRD1 antibody (AB105419)

All lanes:

Western blot - Anti-LMBRD1 antibody (ab105419) at 1 µg/mL

All lanes:

Human brain tissue lysate at 15 µg

Predicted band size: 61 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMBRD1 antibody (AB105419)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMBRD1 antibody (AB105419)

Immunohistochemistry of LMBRD1 in Human brain tissue with ab105419 at 2.5 μg/mL.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human LMBRD1. The exact immunogen used to generate this antibody is proprietary information.

Q9NUN5

Specificity

LMBRD1 antibody is predicted to not cross-react with other LMBRD1 family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LMBRD1 also known as LMBR1 domain containing 1 functions as an essential protein involved in the transport of cobalamin (vitamin B12) across lysosomal membranes. This protein has a molecular mass of approximately 68 kDa. Expression of LMBRD1 occurs in various tissues including the liver and kidney where vitamin B12 metabolism is particularly active.
Biological function summary

LMBRD1 mediates intracellular distribution of vitamin B12 which is vital for proper metabolic functions. It forms part of a complex system with other proteins such as MMACHC and CBLIF that are responsible for cobalamin processing and transport. These interactions highlight the protein’s critical role in maintaining vitamin B12 homeostasis at the cellular level.

Pathways

LMBRD1 participates in metabolic pathways relating to vitamin B12 bioavailability and utilization. It plays a role in the cobalamin metabolic pathway ensuring the conversion of cobalamin into its active forms methylcobalamin and adenosylcobalamin. The interaction with proteins such as MMACHC and CBLF within these pathways illustrates its importance in nutrient metabolism and cellular proliferation processes.

LMBRD1 mutations can cause a condition known as methylmalonic aciduria and homocystinuria which stem from cobalamin processing dysfunction. This protein's role in B12 metabolism makes it relevant for understanding these metabolic disorders. Moreover LMBRD1 interacts with proteins like AMN which are involved in B vitamin absorption processes further connecting it to conditions related to nutrient deficiencies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors (PubMed : 19136951). Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome (PubMed : 27456980). Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (PubMed : 25535791). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity).. Isoform 3. (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV).
See full target information LMBRD1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of genomics 2023:9942663 PubMed37719786

2023

An Analysis of the Gene Expression Associated with Lymph Node Metastasis in Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hongjie Yang,Jiafei Liu,Peishi Jiang,Peng Li,Yuanda Zhou,Zhichun Zhang,Qingsheng Zeng,Min Wang,Luciena Xiao Xiao,Xipeng Zhang,Yi Sun,Siwei Zhu
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