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AB137260

Anti-LMTK3 antibody

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(1 Publication)

Rabbit Polyclonal LMTK3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LMTK3.

View Alternative Names

KIAA1883, TYKLM3, LMTK3, Serine/threonine-protein kinase LMTK3, Lemur tyrosine kinase 3

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human LMTK3. The exact immunogen used to generate this antibody is proprietary information.

Q96Q04

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab137260 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LMTK3 also known as Lemur Tyrosine Kinase 3 is a protein kinase with a molecular weight of approximately 97 kDa. It occurs widely in various tissues notably in the brain lung and reproductive tissues. LMTK3 complements several cellular functions because it modifies other proteins by adding phosphate groups which modulate their activity. Its expression seems to vary according to tissue specificity and physiological conditions.
Biological function summary

The kinase influences many cellular processes including cell signaling and receptor modulation. LMTK3 does not appear to be a part of a larger protein complex but its function impacts numerous downstream signaling networks. Studies suggest that LMTK3 regulates estrogen receptor activity influencing cell proliferation and survival. This makes it a relevant protein in hormone-sensitive tissues and conditions.

Pathways

LMTK3 is involved in key cellular signaling pathways such as the ERK/MAPK and PI3K/AKT. Its activity is related to the regulation of proteins like AKT and ERK which are important for cell proliferation differentiation and survival. These pathways position LMTK3 as an important player in cellular response and adaptation to external and internal signals affecting how cells behave in response to growth factors and stress conditions.

Research associates LMTK3 with breast cancer and neurodegenerative diseases. In breast cancer LMTK3 interacts with estrogen receptors affecting tumor growth and resistance to some therapies. This highlights its potential as a therapeutic target in oncology. In neurodegenerative diseases LMTK3’s connection with proteins like tau suggests a role in neuronal survival and function providing insights into disease progression and possible interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed : 21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).
See full target information LMTK3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 15:2015-2022 PubMed28260052

2017

LMTK3 knockdown retards cell growth and invasion and promotes apoptosis in thyroid cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Lu,Xueli Yuan,Qiang Zhang,Hong Zhang,Baozhong Shen
View all publications
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Product promise

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