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AB82833

Anti-LMX1A antibody

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(1 Publication)

Rabbit Polyclonal LMX1A antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LMX1A conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

LIM homeobox transcription factor 1-alpha, LIM/homeobox protein 1.1, LIM/homeobox protein LMX1A, LMX-1.1, LMX1A

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

WB

applications

Immunogen

Synthetic Peptide within Human LMX1A conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8TE12

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Alternative Products

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Primary Antibodies

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Primary Antibodies

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Purification notes
Crude serum, final bleed.
Storage buffer
Preservative: 0.01% Thimerosal (merthiolate)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LMX1A also known as LIM homeobox transcription factor 1 alpha serves as a transcription factor involved in embryonic development. It belongs to the LIM homeobox gene family and weighs approximately 42 kDa. This protein primarily localizes in the central nervous system and developing limb tissues. It plays an important role in the differentiation and development of dopamine-producing neurons which are important for proper nervous system function.
Biological function summary

The presence of LMX1A is essential for the development of dopaminergic neurons in the midbrain. It functions as part of a complex transcriptional network with other key transcription factors such as NURR1 and PITX3 to regulate genes essential for dopamine synthesis and neuron maintenance. Through its actions LMX1A influences the dopaminergic system contributing to motor control and behavior regulation. This makes it important for studies in neurobiology and developmental biology.

Pathways

LMX1A is an integral component in the Wnt signaling pathway which is vital for maintaining dopaminergic neuron populations. It directly impacts the regulation and expression of genes related to dopamine synthesis. In collaboration with transcription factors like NURR1 LMX1A promotes the production of enzymes necessary for dopamine metabolism. This pathway plays an important role in neuronal survival and connectivity illustrating the connection of LMX1A to other proteins within this system.

Alterations in LMX1A expression or function are linked to Parkinson's disease and neural developmental disorders. In Parkinson's disease the degeneration of dopaminergic neurons occurs where LMX1A plays an important role in neuronal development and maintenance showcasing its potential therapeutic significance. Furthermore downregulation of LMX1A can lead to a disrupted neuronal development illustrating its impact on diseases associated with neurological development while the protein NURR1 is also critically involved in these processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).
See full target information LMX1A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Arthritis research & therapy 27:180 PubMed41013704

2025

The Glycolysis-HIF-1α axis induces IL-1β of macrophages in rheumatoid arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Yimeng Jia,Rongli Li,Linfang Huang,Xunyao Wu,Lidan Zhao,Huaxia Yang,Xin You,Yunyun Fei
View all publications
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Product promise

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