Rabbit Polyclonal LONP1/Lon antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 27 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LONP1.
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- Cellular and molecular life sciences : CMLS 80:2582023Protease-independent control of parthanatos by HtrA2/Omi.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJonas Weiß,Michelle Heib,Thiemo Korn,Justus Hoyer,Johaiber Fuchslocher Chico,Susann Voigt,Tomas Koudelka,Andreas Tholey,Dieter AdamPubMed 37594630
- iScience 26:1071362023Glutamine supplementation reverses manganese neurotoxicity by eliciting the mitochondrial unfolded protein response.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShixuan Zhang,Junrou Zhang,Luli Wu,Li Chen,Piye Niu,Jie LiPubMed 37408687
- Cells 11:2022Differential Expression of Lonp1 Isoforms in Cancer Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGiada Zanini,Valentina Selleri,Anna De Gaetano,Lara Gibellini,Mara Malerba,Anna Vittoria Mattioli,Milena Nasi,Nadezda Apostolova,Marcello PintiPubMed 36497197
- Frontiers in pharmacology 13:8599782022Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuoen Cai,Fabin Lin,Dihang Wu,Chenxin Lin,Huiyun Chen,Yicong Wei,Huidan Weng,Zhiting Chen,Minxia Wu,En Huang,Zucheng Ye,Qinyong YePubMed 35652041
- Cell reports 38:1102542022The portrait of liver cancer is shaped by mitochondrial genetics.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMrittika Chattopadhyay,Edmund Charles Jenkins,Ana Victoria Lechuga-Vieco,Kai Nie,Maria Isabel Fiel,Alexander Rialdi,Ernesto Guccione,Jose Antonio Enriquez,Daniela Sia,Amaia Lujambio,Doris GermainPubMed 35045282
- Cell death & disease 12:7012021ATF5, a putative therapeutic target for the mitochondrial DNA 3243A > G mutation-related disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXinpei Gao,Zhixin Jiang,Xinfeng Yan,Jiping Liu,Fengwen Li,Peng Liu,Jialu Li,Yuehua Wei,Yi Eve Sun,Yinan Zhang,Congrong WangPubMed 34262025
- Nucleic acids research 49:5230-52482021DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPedro Silva-Pinheiro,Carlos Pardo-Hernández,Aurelio Reyes,Lisa Tilokani,Anup Mishra,Raffaele Cerutti,Shuaifeng Li,Dieu-Hien Rozsivalova,Sebastian Valenzuela,Sukru A Dogan,Bradley Peter,Patricio Fernández-Silva,Aleksandra Trifunovic,Julien Prudent,Michal Minczuk,Laurence Bindoff,Bertil Macao,Massimo Zeviani,Maria Falkenberg,Carlo ViscomiPubMed 33956154
- Scientific reports 11:73202021Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1/PARK 7 missense mutants.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRaúl Sánchez-Lanzas,José G CastañoPubMed 33795807
- Nature 590:480-4852021Creatine kinase B controls futile creatine cycling in thermogenic fat.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJanane F Rahbani,Anna Roesler,Mohammed F Hussain,Bozena Samborska,Christien B Dykstra,Linus Tsai,Mark P Jedrychowski,Laurent Vergnes,Karen Reue,Bruce M Spiegelman,Lawrence KazakPubMed 33597756
- Neurotoxicology 82:1-82020General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYulim Lee,Jun Young Heo,Xianshu Ju,Jianchen Cui,Min Jeong Ryu,Min Joung Lee,Boohwi Hong,Sungho Yoo,Jeonghoon Ahn,Yoon Hee Kim,Youngkwon Ko,Woosuk ChungPubMed 33144179
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human LONP1. Database link P36776
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1.00000-5.00000 µg/mL | Notes - |
Species Human | Dilution info 1.00000-5.00000 µg/mL | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Function
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix (PubMed:12198491, PubMed:15870080, PubMed:17579211, PubMed:37327776, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m (PubMed:17579211, PubMed:28377575, PubMed:37327776). MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). May also have a chaperone function in the assembly of inner membrane protein complexes (By similarity). Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome (PubMed:17420247). Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner (PubMed:17420247). May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:14739292, PubMed:17420247).
Alternative names
PRSS15, LONP1, LONHs, Lon protease-like protein, Mitochondrial ATP-dependent protease Lon, Serine protease 15, LONP
Recommended products
Rabbit Polyclonal LONP1/Lon antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 27 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LONP1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human LONP1. Database link P36776
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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5 product images
Western blot - Anti-LONP1/Lon antibody (ab103809)
All lanes: Western blot - Anti-LONP1/Lon antibody (ab103809) at 5 µg/mL
All lanes: Human kidney tissue lysate at 50 µg
Predicted band size: 104 kDa, 106 kDa, 117 kDa
Observed band size: 125 kDa, 135 kDa
Western blot - Anti-LONP1/Lon antibody (ab103809)
All lanes: Western blot - Anti-LONP1/Lon antibody (ab103809) at 5 µg/mL
All lanes: Mouse kidney tissue lysate at 50 µg
Predicted band size: 106 kDa
Western blot - Anti-LONP1/Lon antibody (ab103809)
All lanes: Western blot - Anti-LONP1/Lon antibody (ab103809) at 5 µg/mL
All lanes: HepG2 cell lysate at 50 µg
Predicted band size: 106 kDa
Western blot - Anti-LONP1/Lon antibody (ab103809)
All lanes: Western blot - Anti-LONP1/Lon antibody (ab103809) at 5 µg/mL
Lane 1: LONP1 transfected 293T cell lysate at 25 µg
Lane 2: Non-transfected 293T cell lysate at 25 µg
Predicted band size: 106 kDa
Image collected and cropped by CiteAb under a CC-BY license from the publication
Western blot - Anti-LONP1/Lon antibody (ab103809)
LONP1/Lon western blot using anti-LONP1/Lon antibody ab103809. Publication image and figure legend from Kühl, I., Miranda, M., et al., 2017, Elife, PubMed 29132502.
ab103809 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab103809 please see the product overview.
Immunoblot of several mitochondrial proteins in extracts from L/L, cre and L/L hearts; Loading of 6 different membranes: SDHA, SDHB or VDAC1.
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