Rabbit Polyclonal LONP1/Lon antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 27 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LONP1.
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- Cellular and molecular life sciences : CMLS 80:2582023Protease-independent control of parthanatos by HtrA2/Omi.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJonas Weiß,Michelle Heib,Thiemo Korn,Justus Hoyer,Johaiber Fuchslocher Chico,Susann Voigt,Tomas Koudelka,Andreas Tholey,Dieter AdamPubMed 37594630
- iScience 26:1071362023Glutamine supplementation reverses manganese neurotoxicity by eliciting the mitochondrial unfolded protein response.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShixuan Zhang,Junrou Zhang,Luli Wu,Li Chen,Piye Niu,Jie LiPubMed 37408687
- Cells 11:2022Differential Expression of Lonp1 Isoforms in Cancer Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGiada Zanini,Valentina Selleri,Anna De Gaetano,Lara Gibellini,Mara Malerba,Anna Vittoria Mattioli,Milena Nasi,Nadezda Apostolova,Marcello PintiPubMed 36497197
- Frontiers in pharmacology 13:8599782022Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuoen Cai,Fabin Lin,Dihang Wu,Chenxin Lin,Huiyun Chen,Yicong Wei,Huidan Weng,Zhiting Chen,Minxia Wu,En Huang,Zucheng Ye,Qinyong YePubMed 35652041
- Cell reports 38:1102542022The portrait of liver cancer is shaped by mitochondrial genetics.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMrittika Chattopadhyay,Edmund Charles Jenkins,Ana Victoria Lechuga-Vieco,Kai Nie,Maria Isabel Fiel,Alexander Rialdi,Ernesto Guccione,Jose Antonio Enriquez,Daniela Sia,Amaia Lujambio,Doris GermainPubMed 35045282
- Cell death & disease 12:7012021ATF5, a putative therapeutic target for the mitochondrial DNA 3243A > G mutation-related disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXinpei Gao,Zhixin Jiang,Xinfeng Yan,Jiping Liu,Fengwen Li,Peng Liu,Jialu Li,Yuehua Wei,Yi Eve Sun,Yinan Zhang,Congrong WangPubMed 34262025
- Nucleic acids research 49:5230-52482021DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPedro Silva-Pinheiro,Carlos Pardo-Hernández,Aurelio Reyes,Lisa Tilokani,Anup Mishra,Raffaele Cerutti,Shuaifeng Li,Dieu-Hien Rozsivalova,Sebastian Valenzuela,Sukru A Dogan,Bradley Peter,Patricio Fernández-Silva,Aleksandra Trifunovic,Julien Prudent,Michal Minczuk,Laurence Bindoff,Bertil Macao,Massimo Zeviani,Maria Falkenberg,Carlo ViscomiPubMed 33956154
- Scientific reports 11:73202021Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1/PARK 7 missense mutants.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRaúl Sánchez-Lanzas,José G CastañoPubMed 33795807
- Nature 590:480-4852021Creatine kinase B controls futile creatine cycling in thermogenic fat.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJanane F Rahbani,Anna Roesler,Mohammed F Hussain,Bozena Samborska,Christien B Dykstra,Linus Tsai,Mark P Jedrychowski,Laurent Vergnes,Karen Reue,Bruce M Spiegelman,Lawrence KazakPubMed 33597756
- Neurotoxicology 82:1-82020General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYulim Lee,Jun Young Heo,Xianshu Ju,Jianchen Cui,Min Jeong Ryu,Min Joung Lee,Boohwi Hong,Sungho Yoo,Jeonghoon Ahn,Yoon Hee Kim,Youngkwon Ko,Woosuk ChungPubMed 33144179
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.4
Constituents: PBS- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human LONP1. Database link P36776
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1.00000-5.00000 µg/mL | Notes - |
Species Human | Dilution info 1.00000-5.00000 µg/mL | Notes - |
Associated Products
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3 products for Alternative Product
Target data
Function
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).
Alternative names
LONHs, Lon protease-like protein, Mitochondrial ATP-dependent protease Lon, Serine protease 15, LONP, PRSS15, LONP1
Recommended products
Rabbit Polyclonal LONP1/Lon antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 27 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LONP1.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.4
Constituents: PBS- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human LONP1. Database link P36776
- Purification technique
Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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4 product images
Western blot - Anti-LONP1/Lon antibody (ab103809)
All lanes: Western blot - Anti-LONP1/Lon antibody (ab103809) at 5 µg/mL
All lanes: Human kidney tissue lysate at 50 µg
Predicted band size: 104 kDa, 106 kDa, 117 kDa
Observed band size: 125 kDa, 135 kDa
Western blot - Anti-LONP1/Lon antibody (ab103809)
All lanes: Western blot - Anti-LONP1/Lon antibody (ab103809) at 5 µg/mL
All lanes: Mouse kidney tissue lysate at 50 µg
Predicted band size: 106 kDa
Western blot - Anti-LONP1/Lon antibody (ab103809)
All lanes: Western blot - Anti-LONP1/Lon antibody (ab103809) at 5 µg/mL
All lanes: HepG2 cell lysate at 50 µg
Predicted band size: 106 kDa
Western blot - Anti-LONP1/Lon antibody (ab103809)
All lanes: Western blot - Anti-LONP1/Lon antibody (ab103809) at 5 µg/mL
Lane 1: LONP1 transfected 293T cell lysate at 25 µg
Lane 2: Non-transfected 293T cell lysate at 25 µg
Predicted band size: 106 kDa
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