AB81709

Anti-LOX 1 antibody [23C11]

Name: Anti-LOX 1 antibody [23C11] (ab81709) | Abcam
Brand: Abcam Limited
SKU: AB81709
Price: 510 USD
Availability: InStock

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(8 Publications)

Mouse Monoclonal LOX 1 antibody. Suitable for Flow Cyt, IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OLR1 aa 50 to C-terminus.

View Alternative Names

CLEC8A, LOX1, OLR1, Oxidized low-density lipoprotein receptor 1, Ox-LDL receptor 1, C-type lectin domain family 8 member A, Lectin-like oxidized LDL receptor 1, Lectin-type oxidized LDL receptor 1, LOX-1, Lectin-like oxLDL receptor 1, hLOX-1

2 Images

Flow Cytometry - Anti-LOX 1 antibody [23C11] (AB81709)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-LOX 1 antibody [23C11] (AB81709)

ab81709 was conjugated to PE and used in flow cytometry with PBMC cells. The red line represents the isotype control and the blue line HM2138

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LOX 1 antibody [23C11] (AB81709)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LOX 1 antibody [23C11] (AB81709)

Immunohistochemical analysis of human LOX-1 with ab81709 (1 : 100) in paraffin embedded spleen tissue.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

23C11

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

IHC-P, Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human OLR1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P78380

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µg/mL", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

ab81709 neutralizes the biological activity of LOX 1. It also inhibits Hsp70 binding to dendritic cells and Hsp70 induced antigen cross representation. In vivo, targeting LOX1 with a tumor antigen using anti LOX 1 antibody ab81709 induces anti tumor immunity.

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Properties and storage information

Form

Liquid

Purification notes

Purified and 0.2 µm filtered solution.

Storage buffer

Constituents: PBS, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.. (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis.

See full target information OLR1

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 13:4 PubMed34921134

2021

Knockdown of OLR1 weakens glycolytic metabolism to repress colon cancer cell proliferation and chemoresistance by downregulating SULT2B1 via c-MYC.

Applications

Unspecified application

Species

Unspecified reactive species

Tiancheng Zhao,Yezhou Li,Kexin Shen,Quan Wang,Jiayu Zhang

Cell cycle (Georgetown, Tex.) 19:1466-1477 PubMed32308114

2020

HRD1 prevents atherosclerosis-mediated endothelial cell apoptosis by promoting LOX-1 degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Qingguo Li,Wenying Xuan,Zhijun Jia,Hongyan Li,Min Li,Xiubin Liang,Dongming Su

Oxidative medicine and cellular longevity 2019:5820839 PubMed31871552

2019

Internalization and Transportation of Endothelial Cell Surface K2.3 and K3.1 in Normal Pregnancy and Preeclampsia.

Applications

Unspecified application

Species

Unspecified reactive species

Shinkyu Choi,Ji Aee Kim,Seikwan Oh,Mi Hye Park,Geum Joon Cho,Suk Hyo Suh

Toxicology letters 296:48-62 PubMed30081225

2018

The effects of subacute inhaled multi-walled carbon nanotube exposure on signaling pathways associated with cholesterol transport and inflammatory markers in the vasculature of wild-type mice.

Applications

Unspecified application

Species

Unspecified reactive species

Griffith Davis,JoAnn Lucero,Caitlin Fellers,Jacob D McDonald,Amie K Lund

The British journal of dermatology 177:1367-1375 PubMed28380264

2017

Heat shock protein 70 potentiates interferon alpha production by plasmacytoid dendritic cells: relevance for cutaneous lupus and vitiligo pathogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

C Jacquemin,J Rambert,S Guillet,D Thiolat,N Boukhedouni,M-S Doutre,A-S Darrigade,K Ezzedine,P Blanco,A Taieb,K Boniface,J Seneschal

The Journal of experimental medicine 209:109-21 PubMed22213806

2012

Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells.

Applications

IHC

Species

Human

Dapeng Li,Gabrielle Romain,Anne-Laure Flamar,Dorothée Duluc,Melissa Dullaers,Xiao-Hua Li,Sandra Zurawski,Nathalie Bosquet,Anna Karolina Palucka,Roger Le Grand,Anne O'Garra,Gerard Zurawski,Jacques Banchereau,Sangkon Oh

Immunity 22:551-60 PubMed15894273

2005

Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors.

Applications

ICC/IF, Flow Cyt

Species

Human, Human

Pascale Jeannin,Barbara Bottazzi,Marina Sironi,Andrea Doni,Marco Rusnati,Marco Presta,Virginia Maina,Giovanni Magistrelli,Jean François Haeuw,Guillaume Hoeffel,Nathalie Thieblemont,Nathalie Corvaia,Cecilia Garlanda,Yves Delneste,Alberto Mantovani

Immunity 17:353-62 PubMed12354387

2002

Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation.

Applications

Unspecified application

Species

Human

Yves Delneste,Giovanni Magistrelli,Jean Gauchat,Jean Haeuw,Jean Aubry,Kayo Nakamura,Naoko Kawakami-Honda,Liliane Goetsch,Tatsuya Sawamura,Jean Bonnefoy,Pascale Jeannin

View all publications

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