AB174637

Anti-LRP4 antibody [N207/27] - N-terminal

Name: Anti-LRP4 antibody [N207/27] - N-terminal (ab174637) | Abcam
Brand: Abcam Limited
SKU: AB174637
Price: 510 USD
Availability: InStock
Rating: 4 (2 reviews)

(2 Reviews)

(4 Publications)

Mouse Monoclonal LRP4 antibody. N-terminal. Suitable for WB, ICC/IF and reacts with Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Lrp4 aa 1-350.

View Alternative Names

KIAA0816, LRP10, MEGF7, LRP4, Low-density lipoprotein receptor-related protein 4, LRP-4, Multiple epidermal growth factor-like domains 7

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-LRP4 antibody [N207/27] - N-terminal (AB174637)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LRP4 antibody [N207/27] - N-terminal (AB174637)

4% paraformaldehyde-fixed SK-N-BE (human neuroblastoma cell line) cells stained for LRP4 (green) using ab174637 at 1/100 dilution in ICC/IF. Secondary antibody is Goat Anti-Mouse ATTO 488 at 1 : 100. Actin is detected with Phalloidin Texas Red F-Actin stain (red). The nuclear counterstain is DAPI (blue).

Supplier Data

Western blot - Anti-LRP4 antibody [N207/27] - N-terminal (AB174637)

Lane 1:

Western blot - Anti-LRP4 antibody [N207/27] - N-terminal (ab174637) at 1/500 dilution

Lane 2:

Western blot - Anti-LRP4 antibody [N207/27] - N-terminal (ab174637) at 1/1000 dilution

Lane 3:

Western blot - Anti-LRP4 antibody [N207/27] - N-terminal (ab174637) at 1/2000 dilution

All lanes:

Rat brain membrane lysate

Predicted band size: 212 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

N207/27

Isotype

IgG2a

Carrier free

Reacts with

Rat, Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Mouse Lrp4 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

Q8VI56

Epitope

extracellular domain

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Product details

The clone number has been updated from S207-27 to N207/27, both clone numbers name the same antibody clone.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).

See full target information LRP4

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell biochemistry and function 43:e70116 PubMed40864431

2025

The Extracellular Matrix Agrin Promotes Epicardial Cells Activation and Proliferation Post Myocardial Infarction in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Han,Dinghui Wang,Huiping Yang,Xiaodong Jing,Qiang She,Bin Liu

Scientific reports 15:14865 PubMed40295530

2025

MuSK is a substrate for CaMK2β but this interaction is dispensable for MuSK activation in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Jakob J Prömer,Sara Wolske,Perrine Castets,Geeske M van Woerden,Cinzia Barresi,Kevin C O'Connor,Ruth Herbst

Medicine and science in sports and exercise 52:1477-1484 PubMed31985575

2020

Modification of Neuromuscular Junction Protein Expression by Exercise and Doxorubicin.

Applications

Unspecified application

Species

Unspecified reactive species

Andres Mor Huertas,Aaron B Morton,J Matthew Hinkey,Noriko Ichinoseki-Sekine,Ashley J Smuder

Journal of applied physiology (Bethesda, Md. : 1985) 120:166-77 PubMed26472866

2015

Cervical spinal cord injury exacerbates ventilator-induced diaphragm dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Ashley J Smuder,Elisa J Gonzalez-Rothi,Oh Sung Kwon,Aaron B Morton,Kurt J Sollanek,Scott K Powers,David D Fuller

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-LRP4 antibody [N207/27] - N-terminal

Immunocytochemistry/ Immunofluorescence - Anti-LRP4 antibody [N207/27] - N-terminal (AB174637)

Western blot - Anti-LRP4 antibody [N207/27] - N-terminal (AB174637)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Epitope

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (4)

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