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AB217700

Anti-LRP5 + LRP6 antibody

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(2 Publications)

Rabbit Polyclonal LRP6 antibody. Suitable for IHC-P and reacts with Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human LRP6 aa 450-550 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP5 + LRP6 antibody (AB217700)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP5 + LRP6 antibody (AB217700)

Immunohistochemical analysis of formalin-fixed paraffin-embedded sections of mouse embryo tissue labeling LRP5 + LRP6 with ab217700 at a 1/200 dilution, followed by conjugation to a secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP5 + LRP6 antibody (AB217700)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP5 + LRP6 antibody (AB217700)

Immunohistochemical analysis of formalin-fixed paraffin-embedded sections of rat brain tissue labeling LRP5 + LRP6 with ab217700 at a 1/200 dilution, followed by conjugation to a secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human LRP6 aa 450-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O75581

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Secondary Antibodies

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Primary Antibodies

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Primary Antibodies

AB15580

Anti-Ki67 antibody

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
See full target information LRP6
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

British journal of pharmacology 181:3556-3575 PubMed38804080

2024

Role of LRP5/6/GSK-3β/β-catenin in the differences in exenatide- and insulin-promoted T2D osteogenesis and osteomodulation.

Applications

Unspecified application

Species

Unspecified reactive species

Zijun Chen,Yuxi Wang,Guanhua Zhang,Jian Zheng,Lei Tian,Yingliang Song,Xiangdong Liu

Cell transplantation 29:963689720946020 PubMed32749163

2020

The Combination of and Ligustrazine Protects Against Thrombolysis-Induced Hemorrhagic Transformation Through PKCδ/Marcks Pathway in Cerebral Ischemia Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Ruihuan Pan,Xialin Tang,Huajun Wang,Yan Huang,Kai Huang,Shanshan Ling,Mingchao Zhou,Jun Cai,Hongxia Chen,Yan Huang
View all publications
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Product promise

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