AB24386

Anti-LRP6 antibody

Name: Anti-LRP6 antibody (ab24386) | Abcam
Brand: Abcam Limited
SKU: AB24386
Price: 535 USD
Availability: InStock
Rating: 1 (1 reviews)

(1 Review)

(8 Publications)

Goat Polyclonal LRP6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human LRP6 aa 1500-1600.

View Alternative Names

Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP6 antibody (AB24386)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP6 antibody (AB24386)

ab24386 staining LRP6 in Human Kidney at 4μg/ml by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Sections were subjected to steamed antigen retrieval with citrate buffer pH 6.0, and antibody was visualised with HRP-staining.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human LRP6 aa 1500-1600. The exact immunogen used to generate this antibody is proprietary information.

O75581

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "4-6 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

See full target information LRP6

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 10:611699 PubMed33718112

2021

Hypoxia-Induced miR-137 Inhibition Increased Glioblastoma Multiforme Growth and Chemoresistance Through LRP6.

Applications

Unspecified application

Species

Unspecified reactive species

Dong-Mei Li,Qiu-Dan Chen,Gui-Ning Wei,Jie Wei,Jian-Xing Yin,Jun-Hui He,Xin Ge,Zhu-Mei Shi

The journal of obstetrics and gynaecology research 47:184-197 PubMed32924237

2020

MiR-95-5p involves in the migration and invasion of trophoblast cells by targeting low density lipoprotein receptor-related protein 6.

Applications

Unspecified application

Species

Unspecified reactive species

Huijie Ni,Xiao Wang,Hongmei Qu,Xueli Gao,Xiaoyan Yu

Cancer discovery 10:1038-1057 PubMed32376773

2020

Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Josef Leibold,Marcus Ruscetti,Zhen Cao,Yu-Jui Ho,Timour Baslan,Min Zou,Wassim Abida,Judith Feucht,Teng Han,Francisco M Barriga,Kaloyan M Tsanov,Leah Zamechek,Amanda Kulick,Corina Amor,Sha Tian,Katarzyna Rybczyk,Nelson R Salgado,Francisco J Sánchez-Rivera,Philip A Watson,Elisa de Stanchina,John E Wilkinson,Lukas E Dow,Cory Abate-Shen,Charles L Sawyers,Scott W Lowe

International journal of molecular medicine 44:2201-2212 PubMed31638173

2019

Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xiu-Mei Wang,Xiao-Yi Wang,Yu-Mei Huang,Xia Chen,Mu-Han Lü,Lei Shi,Chang-Ping Li

American journal of translational research 9:715-721 PubMed28337300

2017

Mutation of miR-21 targets endogenous lipoprotein receptor-related protein 6 and nonalcoholic fatty liver disease.

Applications

Unspecified application

Species

Unspecified reactive species

Chang-Ping Li,Hong-Jue Li,Jiao Nie,Xia Chen,Xian Zhou

Journal of translational medicine 12:259 PubMed25240815

2014

MiR-126-3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2.

Applications

Unspecified application

Species

Unspecified reactive species

Chengli Du,Zhen Lv,Linping Cao,Chaofeng Ding,Owusu-Ansah K Gyabaah,Haiyang Xie,Lin Zhou,Jian Wu,Shusen Zheng

Cancer research 73:1900-11 PubMed23302227

2013

Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer.

Applications

Unspecified application

Species

Human

Salahaldin A Tahir,Guang Yang,Alexei Goltsov,Ki-Duk Song,Chengzhen Ren,Jianxiang Wang,Wenjun Chang,Timothy C Thompson

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:3729-42 PubMed21389228

2011

Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Marcel Tawk,Joelle Makoukji,Martin Belle,Cosima Fonte,Amalia Trousson,Thomas Hawkins,Huiliang Li,Said Ghandour,Michael Schumacher,Charbel Massaad

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-LRP6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP6 antibody (AB24386)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (8)

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