Rabbit Polyclonal LRPPRC/GP130 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 15 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LRPPRC aa 600-950.
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- Nature communications 14:42122023The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei Zhou,Wenxi Wang,Yuxin Liang,Ruibin Jiang,Fensheng Qiu,Xiying Shao,Yang Liu,Le Fang,Maowei Ni,Chenhuan Yu,Yue Zhao,Weijia Huang,Jiong Li,Michael J Donovan,Lina Wang,Juan Ni,Dachi Wang,Ting Fu,Jianguo Feng,Xiaojia Wang,Weihong Tan,Xiaohong FangPubMed 37452037
- Zhongguo fei ai za zhi = Chinese journal of lung cancer 25:311-3222022[Comprehensive Analysis of the Relationship between m6A Methylation Patterns and Immune Microenvironment in Lung Adenocarcinoma].Applications:Unspecified applicationReactive species:Unspecified reactive speciesJi Ke,Jian Cui,Xingguo Yang,Xin Du,Bobo Ma,Lei YuPubMed 35599007
- Frontiers in genetics 12:8176722022Mitochondrial-Associated Protein LRPPRC is Related With Poor Prognosis Potentially and Exerts as an Oncogene Maintaining Mitochondrial Function in Pancreatic Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi Wang,Jun Luo,Yuchen Li,Yanrong Lu,Yi Zhang,Bole Tian,Ziyi Zhao,Qiong-Ying HuPubMed 35237297
- Molecular and cellular biology 41:e00103212021The Mammalian Ecdysoneless Protein Interacts with RNA Helicase DDX39A To Regulate Nuclear mRNA Export.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIrfana Saleem,Sameer Mirza,Aniruddha Sarkar,Mohsin Raza,Bhopal Mohapatra,Insha Mushtaq,Jun Hyun Kim,Nitish K Mishra,Mansour A Alsaleem,Emad A Rakha,Fang Qiu,Chittibabu Guda,Hamid Band,Vimla BandPubMed 33941617
- Oncology reports 45:2021LRPPRC contributes to the cisplatin resistance of lung cancer cells by regulating expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYunfeng Hu,Jie Cui,Lei Jin,Yani Su,Xiaozhi ZhangPubMed 33649818
- Cancers 12:2020Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarcus Wurlitzer,Nikolaus Möckelmann,Malte Kriegs,Maren Vens,Maryam Omidi,Konstantin Hoffer,Clara von Bargen,Christina Möller-Koop,Melanie Witt,Conrad Droste,Agnes Oetting,Hannes Petersen,Chia-Jung Busch,Adrian Münscher,Hartmut Schlüter,Till Sebastian Clauditz,Thorsten RieckmannPubMed 32545200
- Frontiers in genetics 10:13932020RNase H1 Regulates Mitochondrial Transcription and Translation the Degradation of 7S RNA.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAurelio Reyes,Joanna Rusecka,Katarzyna Tońska,Massimo ZevianiPubMed 32082360
- Pflugers Archiv : European journal of physiology 472:375-3842020Fiber-specific and whole-muscle LRP130 expression in rested, exercised, and fasted human skeletal muscle.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHashim Islam et. al.PubMed 32065259
- The Prostate 78:426-4342018Metastatic prostate cancer-associated P62 inhibits autophagy flux and promotes epithelial to mesenchymal transition by sustaining the level of HDAC6.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXianhan Jiang,Yiqiao Huang,Xue Liang,Funeng Jiang,Yongzhong He,Tian Li,Guibin Xu,Haibo Zhao,Weiqing Yang,Ganggang Jiang,Zhengming Su,Lingke Jiang,Leyuan LiuPubMed 29383752
- Cell chemical biology 24:614-623.e62017Mitochondrial Chaperonin HSP60 Is the Apoptosis-Related Target for Myrtucommulone.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKatja Wiechmann et. al.PubMed 28457707
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 78% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human LRPPRC aa 600-950. The exact immunogen used to generate this antibody is proprietary information. Database link P42704
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Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/10000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/1000 | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/1000 | Notes - |
Associated Products
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Target data
Function
May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101).
Alternative names
LRP130, LRPPRC, 130 kDa leucine-rich protein, GP130, LRP 130
Recommended products
Rabbit Polyclonal LRPPRC/GP130 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 15 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LRPPRC aa 600-950.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 78% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human LRPPRC aa 600-950. The exact immunogen used to generate this antibody is proprietary information. Database link P42704
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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5 product images
Western blot - Anti-LRPPRC/GP130 antibody (ab97505)
5% SDS-PAGE
All lanes: Western blot - Anti-LRPPRC/GP130 antibody (ab97505) at 1/1000 dilution
Lane 1: H1299 whole cell lysate at 30 µg
Lane 2: HeLa whole cell lysate at 30 µg
Predicted band size: 158 kDa
Immunocytochemistry/ Immunofluorescence - Anti-LRPPRC/GP130 antibody (ab97505)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa using ab97505 at 1/200 dilution. Lower panel is also merged with DNA probe.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRPPRC/GP130 antibody (ab97505)
Immunohistochemical analysis of paraffin-embedded SW480 Xenograft using ab97505 at 1/100 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRPPRC/GP130 antibody (ab97505)
Paraffin embedded human colon cancer tissue stained for LRP130 using ab97505 at 1/100 at dilution in immunohistochemical analysis.
Image collected and cropped by CiteAb under a CC-BY license from the publication
Western blot - Anti-LRPPRC/GP130 antibody (ab97505)
LRPPRC/GP130 western blot using anti-LRPPRC/GP130 antibody ab97505. Publication image and figure legend from Zanon, A., Rakovic, A., et al., 2013, PLoS One, PubMed 24244333.
ab97505 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab97505 please see the product overview.
Co-immunoprecipitation assays for Parkin and candidate binding proteins.Extracts from untransfected HEK293T cells were subjected to immunoprecipitation with anti-Parkin or control IgG antibodies, followed by Western Blot of input and immunoprecipitation (IP) fractions with antibodies against LRPPRC and TOMM70A. The asterisk indicates a non-specific band.
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