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AB111572

Anti-LRRC4C antibody

4

(2 Reviews)

|

(1 Publication)

Rabbit Polyclonal LRRC4C antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LRRC4C aa 1-200.

View Alternative Names

KIAA1580, NGL1, UNQ292/PRO331, LRRC4C, Leucine-rich repeat-containing protein 4C, Netrin-G1 ligand, NGL-1

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-LRRC4C antibody (AB111572)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-LRRC4C antibody (AB111572)

ab111572 at 1/500 dilution staining LRRC4C in methanol-fixed MCF7 cells by Immunofluorescence. Lower image shows cells co-stained with Hoechst 33342.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRC4C antibody (AB111572)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRC4C antibody (AB111572)

Paraffin-embedded human breast cancer tissue stained for LRRC4C using ab111572 at 1/250 dilution in Immunohistochemical analysis.

Western blot - Anti-LRRC4C antibody (AB111572)
  • WB

Unknown

Western blot - Anti-LRRC4C antibody (AB111572)

7.5% SDS-PAGE.

All lanes:

Western blot - Anti-LRRC4C antibody (ab111572) at 1/2000 dilution

All lanes:

MCF7 whole cell lysate at 30 µg

Predicted band size: 71 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LRRC4C aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q9HCJ2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Alternative antigen retrieval method: heat mediated Tris-EDTA buffer, pH 8.0</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Zebrafish": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The LRRC4C protein also known as SRR3 or Leucine Rich Repeat Containing 4C plays a role in neuronal signaling. This protein weighs approximately 83 kDa and shows expression predominantly in the nervous system especially in brain tissue. LRRC4C belongs to a family known for containing leucine-rich repeats which are structures involved in protein-protein interactions.
Biological function summary

LRRC4C influences neuronal synapse development and functioning. It interacts with other synaptic components and may form part of larger molecular complexes at the synapse. Its expression and function suggest it might affect synapse formation stabilization and plasticity important for effective neuronal communication and network stabilization.

Pathways

LRRC4C participates in processes involved in synaptic signaling pathways. It closely interacts with proteins such as neuroligins which are important for synaptic adhesion and communication between neurons. These pathways are essential in maintaining the structure and function of synapses contributing to both neuronal growth and signaling efficiency.

LRRC4C shows potential connections to neurological conditions such as autism spectrum disorder and schizophrenia. Studies suggest that its interaction with proteins like neurexins might influence disease pathogenesis given their roles in synaptic organization and function. Disruptions in these pathways can lead to synaptic imbalances contributing to the symptoms associated with these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May promote neurite outgrowth of developing thalamic neurons.
See full target information LRRC4C
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 30:959-968.e3 PubMed31995766

2020

Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain.

Applications

Unspecified application

Species

Unspecified reactive species

Chih-Hao Yang,Adrian Di Antonio,Gregory W Kirschen,Parul Varma,Jenny Hsieh,Shaoyu Ge
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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