JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB121412

Anti-LRRC55 antibody

0

(1 Review)

|

(3 Publications)

Rabbit Polyclonal LRRC55 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LRRC55 aa 100-250.

View Alternative Names

Leucine-rich repeat-containing protein 55, BK channel auxiliary gamma subunit LRRC55, LRRC55

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRC55 antibody (AB121412)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRC55 antibody (AB121412)

Immunohistochemical staining of paraffin embedded Human stomach tissue shows strong cytoplasmic positivity in parietal cells, using 1/35 ab121412.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LRRC55 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q6ZSA7

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LRRC55 also known as Leucine Rich Repeat Containing 55 is a protein encoded by the LRRC55 gene. Mechanically LRRC55 functions as an auxiliary subunit modulating large-conductance calcium-activated potassium (BK) channels which are key players in maintaining cellular ionic homeostasis. This protein has an approximate mass of 37 kDa. LRRC55 is expressed across various tissues but it has a significant presence in the brain and to lesser extents in other tissues such as the testis and kidney.
Biological function summary

The LRRC55 protein contributes to fine-tuning the physiological properties of BK channels. It is not just a single operator but part of a complex involving these channels. BK channels are vital for regulating neuronal excitability muscle contraction and other fundamental cellular processes. Through modulating these channels LRRC55 helps in sculpting the kinetics and response to calcium therefore impacting the overall behavior of the cells where it is expressed.

Pathways

The role of LRRC55 in modulating BK channels integrates it into critical pathways such as the smooth muscle contraction and neuronal signal transduction pathways. These pathways involve calcium regulation where the BK channels play a pivotal role. LRRC55 relates closely to other proteins like KCNMA1 the main pore-forming subunit of BK channels thereby contributing to the functional properties of these channels in signaling pathways.

LRRC55 has potential links with neurological disorders such as epilepsy due to its critical role in neuronal excitability and signaling. Disruption or dysregulation of BK channels where LRRC55 is an interacting partner may lead to altered synaptic activity and increased susceptibility to such disorders. Additionally aberrations in smooth muscle function linked to LRRC55 impact may hint toward a role in hypertension given the importance of BK channels in regulating vascular tone.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium.
See full target information LRRC55
style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of cell communication and signaling 19:e70022 PubMed40520074

2025

Modulation of podocyte extracellular matrix remodeling in membranous nephropathy by the NFATc3/LRRC55/BK channel pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yaling Guo,Jingliang Min,Baochao Chang,Lei Liu,Jiqiang Zhang,Weidong Chen

Regenerative therapy 20:41-50 PubMed35402663

2022

YY1-induced lncRNA XIST inhibits cartilage differentiation of BMSCs by binding with TAF15 to stabilizing FUT1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Jian-Ying He,Min Cheng,Jia-Lian Ye,Chuan-Hua Peng,Jian Chen,Bin Luo,Xian-Yu Zhang,Qiang Fu

Antioxidants (Basel, Switzerland) 9: PubMed33202933

2020

Hydrogen Sulfide Relaxes Human Uterine Artery via Activating Smooth Muscle BK Channels.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Li,Jin Bai,Yi-Hua Yang,Naoto Hoshi,Dong-Bao Chen
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB109503

Anti-Transferrin antibody [EPR2932(2)] - Serum Loading Control

RabMAb|Recombinant|KO Validated|Lab Essentials|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Transferrin antibody [EPR2932(2)] - Serum Loading Control (AB109503)

  • 5
  • 2
Primary Antibodies

AB117803

Anti-ZNF687 antibody

Immunoprecipitation - Anti-ZNF687 antibody (AB117803)

  • 0
  • 0
Primary Antibodies

AB121685

Anti-ZNF750 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF750 antibody (AB121685)

  • 0
  • 0
Primary Antibodies

AB118800

Anti-ZZZ3 antibody

Western blot - Anti-ZZZ3 antibody (AB118800)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com