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AB84874

Anti-LRRFIP2 antibody [377C3a]

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(1 Publication)

Mouse Monoclonal LRRFIP2 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LRRFIP2.

View Alternative Names

Leucine-rich repeat flightless-interacting protein 2, LRR FLII-interacting protein 2, LRRFIP2

1 Images
Western blot - Anti-LRRFIP2 antibody [377C3a] (AB84874)
  • WB

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Western blot - Anti-LRRFIP2 antibody [377C3a] (AB84874)

Note : actual band size differs from predicted one, because the WB is depicting the recombinant fragment used as immunogen.

All lanes:

Western blot - Anti-LRRFIP2 antibody [377C3a] (ab84874)

All lanes:

immunising recombinant protein

Predicted band size: 82 kDa

Observed band size: 38 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

377C3a

Isotype

IgG2a

Carrier free

No

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human LRRFIP2. The exact immunogen used to generate this antibody is proprietary information.

Q9Y608

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum.Filtered through a 0.22 µm membrane.
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LRRFIP2 or Leucine Rich Repeat Flightless Interacting Protein 2 is a multifunctional protein weighing approximately 82 kDa. It interacts with actin and other cytoskeletal proteins and serves as a regulator of molecular interactions within the cell. LRRFIP2 localizes to the cytoplasm and is expressed in numerous tissues with a notable presence in immune cells. Its mechanical role primarily involves binding to specific nucleotides and transducing signals that subsequently influence cellular activities.
Biological function summary

LRRFIP2 plays a significant role in modulating immune responses and inflammation processes. It participates in forming a complex with Fliih GTPases and other signaling proteins to regulate signal transduction pathways. The protein acts as a mediator in the innate immune system facilitating the cellular response to pathogen-associated molecular patterns (PAMPs) and contributing to the activation of inflammatory pathways that initiate immune defense mechanisms.

Pathways

LRRFIP2 significantly impacts the Wnt/β-catenin and NF-κB pathways. Its interaction with proteins such as GSK3β and TLRs integrates LRRFIP2 into these key signaling cascades affecting gene expression related to cellular growth survival and inflammation. By influencing these pathways LRRFIP2 can alter the balance between pro-inflammatory and anti-inflammatory responses highlighting its role in maintaining cellular homeostasis and immune regulation.

Mutations or dysregulation of LRRFIP2 can associate with inflammatory and autoimmune diseases such as rheumatoid arthritis and Crohn's disease. Its interaction with other proteins like TNF-α and NOD2 links it to pathological conditions where chronic inflammation persists. These associations highlight the therapeutic potential of targeting LRRFIP2 in treatments aimed at reducing inflammation and managing autoimmune responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
See full target information LRRFIP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of gastroenterology and hepatology 33:1407-1412 PubMed29278438

2018

Role of heat shock factor 1 expression in the microenvironment of intrahepatic cholangiocarcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Yoichiro Kawashita,Yuji Morine,Yu Saito,Chie Takasu,Tetsuya Ikemoto,Shuichi Iwahashi,Hiroki Teraoku,Masato Yoshikawa,Satoru Imura,Toshiyuki Yagi,Mitsuo Shimada
View all publications
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Product promise

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