Anti-LRRN4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

LRRN4 also known as Leucine Rich Repeat Neuronal 4 represents a significant protein with a known mass of approximately 90 kDa. This protein shows expression mainly in the central nervous system where it engages in essential mechanical roles. LRRN4 is characterized by its structure which contains leucine-rich repeat domains contributing to its function in cell adhesion and signaling processes. These domains facilitate interactions with other molecules at the cellular level.

Biological function summary

The protein LRRN4 contributes to neurodevelopment and the maintenance of neuronal connections. It often works as part of a protein complex interacting with other proteins to regulate synaptic stability and neural network formation. LRRN4 helps modulate neural activity by influencing the arrangement of synapses ensuring effective communication between neurons throughout development and into adulthood.

Pathways

Research highlights LRRN4's role in neural signaling and plasticity pathways. It plays a part in neurotrophin signaling interacting with proteins such as brain-derived neurotrophic factor (BDNF) which supports neuronal survival and differentiation. Through these pathways LRRN4's functions are linked to processes like synaptic transmission and memory formation interacting with key pathway proteins that determine synaptic strength and plasticity.

Associated diseases and disorders

LRRN4 associates with neurological disorders like autism spectrum disorders and schizophrenia. Abnormal expression or mutations in LRRN4 can disrupt neural connectivity implying its potential role in these conditions. Additionally proteins like neuroligin and neurexin which also affect synaptic connectivity and are connected to LRRN4 play contributory roles in these disorders emphasizing the importance of maintaining normal LRRN4 function for cognitive and neural health.