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AB133372

Anti-LRRN4 antibody

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(3 Publications)

Rabbit Polyclonal LRRN4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human LRRN4.

View Alternative Names

C20orf75, LRRN4, Leucine-rich repeat neuronal protein 4, Neuronal leucine-rich repeat protein 4, NLRR-4

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRN4 antibody (AB133372)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRN4 antibody (AB133372)

ab133372, at 2.5 µg/ml, staining LRRN4 in Formalin-fixed, Paraffin-embedded Human small pancreas by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRN4 antibody (AB133372)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRN4 antibody (AB133372)

ab133372, at 2.5 µg/ml, staining LRRN4 in Formalin-fixed, Paraffin-embedded Human small intestine tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human LRRN4. The exact immunogen used to generate this antibody is proprietary information.

Q8WUT4

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LRRN4 also known as Leucine Rich Repeat Neuronal 4 represents a significant protein with a known mass of approximately 90 kDa. This protein shows expression mainly in the central nervous system where it engages in essential mechanical roles. LRRN4 is characterized by its structure which contains leucine-rich repeat domains contributing to its function in cell adhesion and signaling processes. These domains facilitate interactions with other molecules at the cellular level.
Biological function summary

The protein LRRN4 contributes to neurodevelopment and the maintenance of neuronal connections. It often works as part of a protein complex interacting with other proteins to regulate synaptic stability and neural network formation. LRRN4 helps modulate neural activity by influencing the arrangement of synapses ensuring effective communication between neurons throughout development and into adulthood.

Pathways

Research highlights LRRN4's role in neural signaling and plasticity pathways. It plays a part in neurotrophin signaling interacting with proteins such as brain-derived neurotrophic factor (BDNF) which supports neuronal survival and differentiation. Through these pathways LRRN4's functions are linked to processes like synaptic transmission and memory formation interacting with key pathway proteins that determine synaptic strength and plasticity.

LRRN4 associates with neurological disorders like autism spectrum disorders and schizophrenia. Abnormal expression or mutations in LRRN4 can disrupt neural connectivity implying its potential role in these conditions. Additionally proteins like neuroligin and neurexin which also affect synaptic connectivity and are connected to LRRN4 play contributory roles in these disorders emphasizing the importance of maintaining normal LRRN4 function for cognitive and neural health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play an important role in hippocampus-dependent long-lasting memory.
See full target information LRRN4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Aging 14:9317-9337 PubMed36446386

2022

High SURF4 expression is associated with poor prognosis of breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jingtong Zhai,Jiashu Han,Cong Li,Fengzhu Guo,Fei Ma,Binghe Xu

Cancer cell international 22:158 PubMed35440048

2022

Prognostic value and biological function of LRRN4 in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Xu,Yulin Chen,Feiwu Long,Junman Ye,Xue Li,Qiaorong Huang,Dejiao Yao,Xiaoli Wang,Jin Zhao,Wentong Meng,Xianming Mo,Ran Lu,Chuanwen Fan,Tao Zhang

Genetics and molecular biology 45:e20210138 PubMed34919118

2021

The expression of LRRN4 was correlated with the progression and prognosis of colon adenocarcinoma (COAD) patients.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxian Zhang,Jianlan Xie,Diangang Liu,Shengtao Zhu,Shutian Zhang
View all publications
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Product promise

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