Anti-LRRTM4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

LRRTM4 also known as Leucine Rich Repeat Transmembrane Neuronal 4 is a protein that plays a critical role in synaptic organization. It is a transmembrane protein mainly found in the postsynaptic density of excitatory synapses. LRRTM4 has a molecular mass of approximately 65 kDa. It is highly expressed in the brain particularly in regions involved in cognitive functions such as the hippocampus and cortex.

Biological function summary

The protein facilitates synapse development and maintenance influencing synaptic transmission by interacting with presynaptic partners. LRRTM4 acts as a synaptic organizer and is part of the postsynaptic membrane complex. It works closely with other synaptic proteins to facilitate synaptogenesis and maintain synaptic plasticity essential for learning and memory processes.

Pathways

LRRTM4 operates within neural communication pathways critical for synaptic development. It interacts with neurexins which are essential to the presynaptic organization forming complexes that aid neurotransmitter release. Furthermore it is involved in the organization of excitatory synapse pathways similar to its relative protein LRRTM2 which also shares a role in excitatory synaptic function.

Associated diseases and disorders

The dysregulation of LRRTM4 expression has been linked to neurodevelopmental disorders such as autism spectrum disorders (ASD) and schizophrenia. Aberrant expression or function of LRRTM4 can contribute to the synaptic deficits observed in these conditions. The protein is associated with synaptic proteins like neuroligins which are implicated in similar neurodevelopmental disorders further emphasizing its importance in maintaining synaptic health.