JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB234876

Anti-LRRTM4 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal LRRTM4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LRRTM4 aa 250-450.

View Alternative Names

UNQ3075/PRO9907, LRRTM4, Leucine-rich repeat transmembrane neuronal protein 4

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRTM4 antibody (AB234876)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRTM4 antibody (AB234876)

Paraffin-embedded human brain tissue stained for LRRTM4 using ab234876 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-LRRTM4 antibody (AB234876)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LRRTM4 antibody (AB234876)

HepG2 (Human liver hepatocellular carcinoma cell line) cells labeling LRRTM4 using ab234876 at 1/100 dilution inICC/IF, followed by Alexa Fluor 488® congugated Goat Anti-Rabbit IgG (H+L).

Western blot - Anti-LRRTM4 antibody (AB234876)
  • WB

Supplier Data

Western blot - Anti-LRRTM4 antibody (AB234876)

All lanes:

Western blot - Anti-LRRTM4 antibody (ab234876) at 1/1000 dilution

All lanes:

Mouse brain lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 67 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human LRRTM4 aa 250-450. The exact immunogen used to generate this antibody is proprietary information.

Q86VH4

style
left-column

Complementary Products

Primary Antibodies

AB234867

Anti-Use1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Use1 antibody (AB234867)

  • 0
  • 0
Primary Antibodies

AB185546

Anti-WAVE 1 antibody [EPR15021] - N-terminal

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-WAVE 1 antibody [EPR15021] - N-terminal (AB185546)

  • 0
  • 0
Primary Antibodies

AB68428

Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Multiplex immunohistochemistry - Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker (AB68428)

  • 5
  • 19
Primary Antibodies

AB171088

Anti-TCR beta F1 antibody [8A3]

Flow Cytometry - Anti-TCR beta F1 antibody [8A3] (AB171088)

  • 5
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LRRTM4 also known as Leucine Rich Repeat Transmembrane Neuronal 4 is a protein that plays a critical role in synaptic organization. It is a transmembrane protein mainly found in the postsynaptic density of excitatory synapses. LRRTM4 has a molecular mass of approximately 65 kDa. It is highly expressed in the brain particularly in regions involved in cognitive functions such as the hippocampus and cortex.
Biological function summary

The protein facilitates synapse development and maintenance influencing synaptic transmission by interacting with presynaptic partners. LRRTM4 acts as a synaptic organizer and is part of the postsynaptic membrane complex. It works closely with other synaptic proteins to facilitate synaptogenesis and maintain synaptic plasticity essential for learning and memory processes.

Pathways

LRRTM4 operates within neural communication pathways critical for synaptic development. It interacts with neurexins which are essential to the presynaptic organization forming complexes that aid neurotransmitter release. Furthermore it is involved in the organization of excitatory synapse pathways similar to its relative protein LRRTM2 which also shares a role in excitatory synaptic function.

The dysregulation of LRRTM4 expression has been linked to neurodevelopmental disorders such as autism spectrum disorders (ASD) and schizophrenia. Aberrant expression or function of LRRTM4 can contribute to the synaptic deficits observed in these conditions. The protein is associated with synaptic proteins like neuroligins which are implicated in similar neurodevelopmental disorders further emphasizing its importance in maintaining synaptic health.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).
See full target information LRRTM4
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell 185:3356-3374.e22 PubMed36055199

2022

Sublethal cytochrome c release generates drug-tolerant persister cells.

Applications

Unspecified application

Species

Unspecified reactive species

Halime Kalkavan,Mark J Chen,Jeremy C Crawford,Giovanni Quarato,Patrick Fitzgerald,Stephen W G Tait,Colin R Goding,Douglas R Green
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com