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AB89719

Anti-LSAMP antibody [MM0445-3H44]

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(1 Publication)

Mouse Monoclonal LSAMP antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LSAMP.

View Alternative Names

IGLON3, LAMP, LSAMP, Limbic system-associated membrane protein, IgLON family member 3

1 Images
Western blot - Anti-LSAMP antibody [MM0445-3H44] (AB89719)
  • WB

Supplier Data

Western blot - Anti-LSAMP antibody [MM0445-3H44] (AB89719)

All lanes:

Western blot - Anti-LSAMP antibody [MM0445-3H44] (ab89719)

Predicted band size: 37 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0445-3H44

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LSAMP.

Q13449

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The limbic system-associated membrane protein (LSAMP) also known as IgLON5 is a protein with a mass of around 64 kDa. It is an important component of the neuronal membrane and found heavily expressed in the limbic system which includes areas like the hippocampus and amygdala. LSAMP localizes at synaptic junctions suggesting its active role in neuron-to-neuron communication. It belongs to the immunoglobulin superfamily and is known for facilitating cell adhesion processes in the brain.
Biological function summary

LSAMP influences the growth and connectivity of neurons. It plays an important role in neuronal development guiding axonal processes and stabilizing synaptic contacts. LSAMP does not function alone; it forms part of a complex with several other cell adhesion molecules working collaboratively to influence neural circuit formation and synaptic plasticity. These actions are important for the correct wiring of nerve cells during development and learning processes.

Pathways

LSAMP influences the cellular signaling related to growth and connectivity. It is active in pathways such as the MAPK signaling pathway which affects cell division survival and differentiation. LSAMP interacts with proteins like NCAM (neural cell adhesion molecule) and L1CAM (L1 cell adhesion molecule) which are significant in these pathways. These proteins work together to modulate molecular mechanisms that underlie neural network stability and response to environmental stimuli.

LSAMP has been connected to abnormalities in neural circuits leading to potential links with psychiatric disorders such as schizophrenia and anxiety. Research indicates that alterations in LSAMP expression or function can disrupt neural development and contribute to these disorders. It may act in conjunction with factors like BDNF (brain-derived neurotrophic factor) during disease pathogenesis highlighting the complex interactions that underpin these neurosignificant disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity).
See full target information LSAMP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Discover oncology 15:606 PubMed39480592

2024

LINC00342 regulates the PI3K-AKT signaling pathway via the miR-149-5p/FGF11 axis and affects the progression of oral cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yimiao Chen,Yanchun Wang,Wenbo Zhang
View all publications
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