Rabbit Polyclonal LSDP5 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLIN5 aa 300 to C-terminus.
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Publications
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- Cell death & disease 14:2482023Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency.Applications:Unspecified applicationReactive species:Unspecified reactive speciesÁngel Gaudioso,Xuntian Jiang,Josefina Casas,Edward H Schuchman,María Dolores LedesmaPubMed 37024473
- International journal of molecular sciences 22:2021Leptin Reduces Plin5 mA Methylation through FTO to Regulate Lipolysis in Piglets.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDongqin Wei,Qian Sun,Yizhou Li,Chaowei Li,Xinjian Li,Chao SunPubMed 34638947
- Translational cancer research 9:2919-29302020Methylation of is a crucial biomarker and is involved in ovarian cancer development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYujie Zhao,Dong Xu,Ying Wan,Qinghua XiPubMed 35117648
- Molecular medicine reports 20:879-8862019Lipid storage droplet protein 5 reduces sodium palmitate‑induced lipotoxicity in human normal liver cells by regulating lipid metabolism‑related factors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXueqiang Ma et. al.PubMed 31173228
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human PLIN5 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q00G26
Reactivity data
Select an application| WB | |
|---|---|
| Human | Expected |
| Mouse | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/1000 - 1/5000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000 - 1/5000 | Notes - |
Target data
Function
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity).
Alternative names
LSDP5, OXPAT, PAT-1, PLIN5, Perilipin-5, Lipid storage droplet protein 5
Recommended products
Rabbit Polyclonal LSDP5 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLIN5 aa 300 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human PLIN5 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q00G26
- Purification technique
- Affinity purification Protein G
- Concentration
- Purification notes
Purity >95%.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LSDP5 also known as PLIN5 or Perilipin 5 is a protein that plays an important role in lipid droplet formation and regulation. Its molecular mass is approximately 52 kDa. This protein is mainly expressed in tissues with high lipid metabolism such as muscle and liver. LSDP5 localizes to the surface of lipid droplets where it regulates triglyceride storage and release connecting to various metabolic processes.
- Biological function summary
The protein contributes to the organization of lipid droplets and regulation of lipid storage in the cell. It is not typically part of a large protein complex. By modulating lipid droplet formation LSDP5 controls the flow of fatty acids in and out of these storage organelles. This action influences energy balance in cells and aids adaptation to metabolic changes supporting both lipid storage and mobilization as needed.
- Pathways
The protein influences energy homeostasis and lipid metabolism pathways notably the peroxisome proliferator-activated receptor (PPAR) pathway. It works in association with other lipid-related proteins including perilipin 1 and adipose triglyceride lipase coordinating lipid storage and hydrolysis. These interactions help regulate the balance between storage and use of lipids impacting mitochondrial energy production.
- Associated diseases and disorders
LSDP5 is connected to metabolic conditions like obesity and type 2 diabetes. Aberrations in its expression or function may lead to dysregulated lipid storage contributing to these metabolic disorders. It interacts with proteins such as PGC-1α which is involved in managing mitochondrial biogenesis and energy expenditure linking it to disease states characterized by impaired energy metabolism.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-LSDP5 antibody (ab222811)
All lanes: Western blot - Anti-LSDP5 antibody (ab222811) at 1/1000 dilution
Lane 1: Mouse kidney lysate
Lane 2: Mouse brain lysate
SecondaryAll lanes: Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 51 kDa
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