JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB222811

Anti-LSDP5 antibody

5

(1 Review)

|

(5 Publications)

Rabbit Polyclonal LSDP5 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLIN5 aa 300 to C-terminus.

View Alternative Names

LSDP5, OXPAT, PAT-1, PLIN5, Perilipin-5, Lipid storage droplet protein 5

1 Images
Western blot - Anti-LSDP5 antibody (AB222811)
  • WB

Supplier Data

Western blot - Anti-LSDP5 antibody (AB222811)

All lanes:

Western blot - Anti-LSDP5 antibody (ab222811) at 1/1000 dilution

Lane 1:

Mouse kidney lysate

Lane 2:

Mouse brain lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 51 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PLIN5 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q00G26

style
left-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB215270

Anti-PPAR alpha antibody

Flow Cytometry (Intracellular) - Anti-PPAR alpha antibody (AB215270)

  • 0
  • 0
Primary Antibodies

AB128568

Anti-CPT1A antibody [8F6AE9]

BOND RX™ Validated|KO Validated

Western blot - Anti-CPT1A antibody [8F6AE9] (AB128568)

  • 5
  • 5
Primary Antibodies

AB108323

Anti-Perilipin 2 antibody [EPR3713]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

  • 4
  • 3
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LSDP5 also known as PLIN5 or Perilipin 5 is a protein that plays an important role in lipid droplet formation and regulation. Its molecular mass is approximately 52 kDa. This protein is mainly expressed in tissues with high lipid metabolism such as muscle and liver. LSDP5 localizes to the surface of lipid droplets where it regulates triglyceride storage and release connecting to various metabolic processes.
Biological function summary

The protein contributes to the organization of lipid droplets and regulation of lipid storage in the cell. It is not typically part of a large protein complex. By modulating lipid droplet formation LSDP5 controls the flow of fatty acids in and out of these storage organelles. This action influences energy balance in cells and aids adaptation to metabolic changes supporting both lipid storage and mobilization as needed.

Pathways

The protein influences energy homeostasis and lipid metabolism pathways notably the peroxisome proliferator-activated receptor (PPAR) pathway. It works in association with other lipid-related proteins including perilipin 1 and adipose triglyceride lipase coordinating lipid storage and hydrolysis. These interactions help regulate the balance between storage and use of lipids impacting mitochondrial energy production.

LSDP5 is connected to metabolic conditions like obesity and type 2 diabetes. Aberrations in its expression or function may lead to dysregulated lipid storage contributing to these metabolic disorders. It interacts with proteins such as PGC-1α which is involved in managing mitochondrial biogenesis and energy expenditure linking it to disease states characterized by impaired energy metabolism.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players : ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity).
See full target information PLIN5
style
left-column

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 14:248 PubMed37024473

2023

Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Ángel Gaudioso,Xuntian Jiang,Josefina Casas,Edward H Schuchman,María Dolores Ledesma

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9:e2104291 PubMed36031387

2022

Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.

Applications

Unspecified application

Species

Unspecified reactive species

Marcos Rios Garcia,Bettina Meissburger,Jessica Chan,Roldan M de Guia,Frits Mattijssen,Stephanie Roessler,Andreas L Birkenfeld,Nathanael Raschzok,Fabien Riols,Janina Tokarz,Maude Giroud,Manuel Gil Lozano,Goetz Hartleben,Peter Nawroth,Mark Haid,Miguel López,Stephan Herzig,Mauricio Berriel Diaz

International journal of molecular sciences 22: PubMed34638947

2021

Leptin Reduces Plin5 mA Methylation through FTO to Regulate Lipolysis in Piglets.

Applications

Unspecified application

Species

Unspecified reactive species

Dongqin Wei,Qian Sun,Yizhou Li,Chaowei Li,Xinjian Li,Chao Sun

Translational cancer research 9:2919-2930 PubMed35117648

2020

Methylation of is a crucial biomarker and is involved in ovarian cancer development.

Applications

Unspecified application

Species

Unspecified reactive species

Yujie Zhao,Dong Xu,Ying Wan,Qinghua Xi

Molecular medicine reports 20:879-886 PubMed31173228

2019

Lipid storage droplet protein 5 reduces sodium palmitate‑induced lipotoxicity in human normal liver cells by regulating lipid metabolism‑related factors.

Applications

Unspecified application

Species

Unspecified reactive species

Xueqiang Ma,Feiyong Cheng,Keyu Yuan,Kexiang Jiang,Tieming Zhu
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com