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AB201159

Anti-LSM11 antibody

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(2 Publications)

Rabbit Polyclonal LSM11 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LSM11 aa 100-350.

View Alternative Names

U7 snRNA-associated Sm-like protein LSm11, LSM11

1 Images
Western blot - Anti-LSM11 antibody (AB201159)
  • WB

Supplier Data

Western blot - Anti-LSM11 antibody (AB201159)

All lanes:

Western blot - Anti-LSM11 antibody (ab201159) at 1/500 dilution

Lane 1:

HeLa cell lysate

Lane 2:

Jurkat cell lysate

Lane 3:

HepG2 cell lysate

Predicted band size: 40 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human LSM11 aa 100-350. The exact immunogen used to generate this antibody is proprietary information.

P83369

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/500", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LSM11 also known as U7 snRNP protein homolog is an important component in the spliceosomal snRNP complex specifically associated with U7 snRNP. LSM11 consists of a molecular mass of approximately 56 kDa. This protein expresses primarily in the nucleus where it plays a significant role in the processing of histone pre-mRNA. The mechanical action of LSM11 involves binding to RNA and facilitating the assembly of snRNP complexes which are essential in the maturation of histone transcripts.
Biological function summary

LSM11 acts within the U7 snRNP complex interacting with other snRNP proteins to ensure proper pre-mRNA cleavage and polyadenylation inhibition. This makes LSM11 essential for the correct formation of mature histone mRNA as histones require maturation without polyadenylation. The lack of poly-A tails in histone mRNA is vital for its role during DNA synthesis linking LSM11 directly to the cell cycle's intricacies. Its function is tightly regulated with multiple proteins interacting with LSM11 to modulate its activity within the histone gene expression pathway.

Pathways

LSM11 functionally integrates into the histone pre-mRNA processing pathway. This pathway critically contributes to cell cycle regulation particularly during DNA replication. LSM11 interacts with other key proteins such as FLASH and the U7 snRNA facilitating precise mRNA processing. Additionally LSM11 forms important interactions within the spliceosomal complex supporting the proper execution of splicing-related tasks necessary for cellular proliferation.

LSM11 has links to cell cycle-related abnormalities such as certain cancers where histone mRNA maturation is disrupted. Aberrant expression or functional disruption of LSM11 can lead to faulty histone mRNA processing contributing to tumorigenesis. The protein's association with other factors like FUS which also plays a role in RNA binding and processing highlights the complex interactions required to maintain normal cellular functions. Defects in LSM11 alongside disruptions in related proteins can manifest in various cancers where cell cycle regulation is impaired.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed : 11574479, PubMed : 16914750, PubMed : 33230297). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed : 11574479, PubMed : 16914750). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to the Sm-binding site of U7 snRNA (PubMed : 11574479, PubMed : 16914750).
See full target information LSM11
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 52:10504-10519 PubMed39189459

2024

Novel function of U7 snRNA in the repression of HERV1/LTR12s and lincRNAs in human cells.

Applications

Unspecified application

Species

Unspecified reactive species

Patrycja Plewka,Michal W Szczesniak,Agata Stepien,Robert Pasieka,Elzbieta Wanowska,Izabela Makalowska,Katarzyna Dorota Raczynska

Neuroscience bulletin 37:1271-1288 PubMed34165772

2021

Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Li,Shihao Wu,Xia Ma,Xiao Li,Tianlin Cheng,Zhifang Chen,Jing Wu,Longbao Lv,Ling Li,Liqi Xu,Wenchao Wang,Yingzhou Hu,Haisong Jiang,Yong Yin,Zilong Qiu,Xintian Hu
View all publications
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