JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB236396

Anti-LSM11 antibody [OTI2G7]

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Monoclonal LSM11 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LSM11.
1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSM11 antibody [OTI2G7] (AB236396)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSM11 antibody [OTI2G7] (AB236396)

Paraffin-embedded human prostate carcinoma tissue stained for LSM11 using ab236396 at 1/2000 in immunohistochemical analysis.

Heat-induced epitope retrieval was performed using 1 mM EDTA in 10 mM TRis buffer (pH 8.5) at 120°C for 3 minutes.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI2G7

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LSM11.

P83369

style
left-column

Alternative Products

Primary Antibodies

AB201159

Anti-LSM11 antibody

Western blot - Anti-LSM11 antibody (AB201159)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB8420

Anti-FLASH antibody

Immunocytochemistry/ Immunofluorescence - Anti-FLASH antibody (AB8420)

  • 3
  • 2
Primary Antibodies

AB221166

Anti-SLBP antibody

Immunocytochemistry/ Immunofluorescence - Anti-SLBP antibody (AB221166)

  • 0
  • 0
Primary Antibodies

AB307837

Anti-NPAT antibody [27/NPAT]

Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-NPAT antibody [27/NPAT] (AB307837)

  • 0
  • 0
Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

  • 5
  • 19
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/2000", "IHCP-species-notes": "<p>Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 minutes.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Purified from cell culture supernatant.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LSM11 also known as U7 snRNP protein homolog is an important component in the spliceosomal snRNP complex specifically associated with U7 snRNP. LSM11 consists of a molecular mass of approximately 56 kDa. This protein expresses primarily in the nucleus where it plays a significant role in the processing of histone pre-mRNA. The mechanical action of LSM11 involves binding to RNA and facilitating the assembly of snRNP complexes which are essential in the maturation of histone transcripts.
Biological function summary

LSM11 acts within the U7 snRNP complex interacting with other snRNP proteins to ensure proper pre-mRNA cleavage and polyadenylation inhibition. This makes LSM11 essential for the correct formation of mature histone mRNA as histones require maturation without polyadenylation. The lack of poly-A tails in histone mRNA is vital for its role during DNA synthesis linking LSM11 directly to the cell cycle's intricacies. Its function is tightly regulated with multiple proteins interacting with LSM11 to modulate its activity within the histone gene expression pathway.

Pathways

LSM11 functionally integrates into the histone pre-mRNA processing pathway. This pathway critically contributes to cell cycle regulation particularly during DNA replication. LSM11 interacts with other key proteins such as FLASH and the U7 snRNA facilitating precise mRNA processing. Additionally LSM11 forms important interactions within the spliceosomal complex supporting the proper execution of splicing-related tasks necessary for cellular proliferation.

LSM11 has links to cell cycle-related abnormalities such as certain cancers where histone mRNA maturation is disrupted. Aberrant expression or functional disruption of LSM11 can lead to faulty histone mRNA processing contributing to tumorigenesis. The protein's association with other factors like FUS which also plays a role in RNA binding and processing highlights the complex interactions required to maintain normal cellular functions. Defects in LSM11 alongside disruptions in related proteins can manifest in various cancers where cell cycle regulation is impaired.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed : 11574479, PubMed : 16914750, PubMed : 33230297). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed : 11574479, PubMed : 16914750). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to the Sm-binding site of U7 snRNA (PubMed : 11574479, PubMed : 16914750).
See full target information LSM11

Alternative Names

U7 snRNA-associated Sm-like protein LSm11, LSM11
style
left-column

Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Digestive diseases and sciences 70:1395-1410 PubMed39961962

2025

LRRC25 Is a Potential Biomarker for Predicting Immunotherapy Response in Patients with Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zhensong Yang,Bin Yu,Jinchen Hu,Lixin Jiang,Mi Jian
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com