Anti-LSM2 antibody [EPR7216] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

LSM2 also known as Like-Smith 2 is a protein involved in RNA processing and stabilization. It has a mass of approximately 14 kDa. This protein is mainly expressed in the cytoplasm and nucleus and its presence is critical in cells with active RNA metabolism. The structure of LSM2 enables it to participate in RNA decay and splicing pathways making it an important player in RNA regulation.

Biological function summary

Proteins coordinate complex molecular processes within cells. LSM2 is part of the Lsm1-7 complex which binds to the 3' ends of mRNA and facilitates mRNA decapping and decay. This complex supports RNA metabolism by modulating mRNA stability and is essential for proper cellular function and response to environmental changes.

Pathways

The functions of LSM2 integrate into RNA processing pathways like mRNA decay and splicing. In the mRNA decay pathway LSM2 through the Lsm1-7 complex works alongside decapping proteins to regulate mRNA turnover influencing gene expression levels. Additionally in splicing LSM2 influences the splicing machinery interacting with proteins like U6 snRNA ensuring accurate splicing of pre-mRNA.

Associated diseases and disorders

Researchers have linked abnormalities in LSM2 function to neurodegenerative diseases such as spinal muscular atrophy. Mutations or malfunctions in LSM2 disrupt RNA processing especially mRNA decay leading to improper gene expression. These disruptions can involve proteins like SMN (Survival Motor Neuron) highlighting LSM2's role in maintaining neuron integrity and function.