Anti-LSM7 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

LSM7 also known as U6 snRNA-associated Sm-like protein LSm7 is a part of the Sm-like family of proteins. This protein has a molecular mass of approximately 9 kDa and is expressed in various tissues with significant presence in the cytoplasm and nucleus. LSM7 predominantly exists as part of the LSm complex that plays an essential role in RNA processing methods.

Biological function summary

LSM7 interacts within the LSm complex which aids in the stabilization and degradation of RNA molecules such as the U6 snRNA. This complex consisting of several proteins ensures the correct splicing of pre-mRNA into mature mRNA which is important for proper gene expression and cellular function. LSM7's binding to U6 snRNA strengthens its involvement in the formation of ribonucleoproteins necessary for RNA splicing.

Pathways

LSM7 participates in the spliceosome assembly and mRNA decay pathways. In the spliceosome LSM7 as part of the LSm complex interacts with proteins such as SmB and SmD ensuring correct splice site recognition and exon joining. In mRNA decay LSM7 facilitates the removal of defective or unnecessary RNA which is significant for maintaining cellular homeostasis by involving proteins like Pat1 and Dcp1.

Associated diseases and disorders

LSM7's dysfunction has connections to autoimmune diseases such as systemic lupus erythematosus (SLE) as well as neurodegenerative disorders. In SLE antibodies target components of the spliceosome disrupting normal immune function. Additionally its interaction with proteins like U6 snRNA-related Sm proteins highlights its potential role in the development of these conditions emphasizing the importance of LSM7 in maintaining healthy cellular processes.