Skip to main content

Rabbit Polyclonal LSR antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Mouse Lipolysis-stimulated lipoprotein receptor aa 1-250.

Be the first to review this product! Submit a review

Images

Western blot - Anti-LSR antibody (AB232780), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-LSR antibody (AB232780), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSR antibody (AB232780), expandable thumbnail
  • Western blot - Anti-LSR antibody (AB232780), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSR antibody (AB232780), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.011% Proclin 300
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Mouse Lipolysis-stimulated lipoprotein receptor aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q99KG5

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-PICC/IF
Human
Expected
Expected
Tested
Mouse
Tested
Tested
Expected
Rat
Tested
Expected
Expected

Tested
Tested

Species

Mouse

Dilution info

0.5-2 µg/mL

Notes

-

Species

Rat

Dilution info

0.5-2 µg/mL

Notes

-

Expected
Expected

Species

Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Tested
Tested

Species

Mouse

Dilution info

5-20 µg/mL

Notes

-

Expected
Expected

Species

Rat, Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Tested
Tested

Species

Human

Dilution info

5-20 µg/mL

Notes

-

Expected
Expected

Species

Mouse, Rat

Dilution info

Use at an assay dependent concentration.

Notes

-

Associated Products

Select an associated product type

3 products for Alternative Product

Target data

Function

Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal LSR antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Mouse Lipolysis-stimulated lipoprotein receptor aa 1-250.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Mouse Lipolysis-stimulated lipoprotein receptor aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q99KG5
Purification technique

Affinity purification Immunogen

Concentration
Loading...
Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The LSR protein also known as Lipolysis Stimulated Lipoprotein Receptor functions mechanically as a component of the plasma membrane where it assists in lipid metabolism. It has a mass of approximately 68 kDa and plays an important role in endocytosis and binding of apolipoproteins. LSR is expressed significantly in liver and intestinal tissues. Researchers often study it for its involvement in lipid management in the human body.

Biological function summary

LSR interacts with other proteins to form a multimeric complex that regulates lipid processing. Its presence is essential for maintaining lipid homeostasis by binding chylomicrons and cholesterol-rich lipoproteins. The LSR complex plays a significant role in managing body lipid levels and maintaining cellular health. These processes contribute to the efficient transport and clearance of dietary fats which are essential functions in metabolic regulation.

Pathways

The activity of the LSR protein is integral to the lipid metabolism and cholesterol homeostasis pathways. Within these pathways LSR collaborates with proteins like APOB and APOE to facilitate lipid uptake and processing. It functions by enabling the clearance of chylomicron remnants and very low-density lipoprotein particles from the bloodstream maintaining lipid balance and preventing disorders related to lipid accumulation.

Associated diseases and disorders

The dysfunction or altered expression of LSR can associate with hyperlipidemia and atherosclerosis. These conditions result from impaired lipid uptake and clearance leading to elevated blood lipid levels. LSR's interaction with apolipoproteins such as APOB links its activities to the metabolic disturbances observed in these diseases. Understanding LSR's role in lipid mechanisms provides potential avenues for therapeutic interventions targeting lipid-related disorders.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

6 product images

  • Western blot - Anti-LSR antibody (ab232780), expandable thumbnail

    Western blot - Anti-LSR antibody (ab232780)

    All lanes: Western blot - Anti-LSR antibody (ab232780) at 3 µg/mL

    Lane 1: Rat liver tissue lysate

    Lane 2: Mouse liver tissue lysate

    Lane 3: HepG2 (human liver hepatocellular carcinoma cell line) cell lysate

    Secondary

    All lanes: HRP-Linked Guinea pig Anti-Rabbit Ab at 1/2000 dilution

    Predicted band size: 71 kDa

  • Immunocytochemistry/ Immunofluorescence - Anti-LSR antibody (ab232780), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-LSR antibody (ab232780)

    HepG2 (human liver hepatocellular carcinoma cell line) cells stained for LSR using ab232780 at 20μg/mL in ICC/IF. FITC-labeled secondary antibody.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSR antibody (ab232780), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSR antibody (ab232780)

    Formalin-fixed, paraffin-embedded mouse cerebrum tissue stained for LSR using ab232780 at 20μg/mL in immunohistochemical analysis. DAB staining.

  • Western blot - Anti-LSR antibody (ab232780), expandable thumbnail

    Western blot - Anti-LSR antibody (ab232780)

    All lanes: Western blot - Anti-LSR antibody (ab232780) at 2 µg/mL

    All lanes: Recombinant mouse LSR protein

    Predicted band size: 71 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSR antibody (ab232780), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSR antibody (ab232780)

    Formalin-fixed, paraffin-embedded mouse testis tissue stained for LSR using ab232780 at 20μg/mL in immunohistochemical analysis. DAB staining.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSR antibody (ab232780), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSR antibody (ab232780)

    Formalin-fixed, paraffin-embedded mouse heart tissue stained for LSR using ab232780 at 20 μg/mL in immunohistochemical analysis. DAB staining.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com