Anti-LSS antibody [EPR6704(B)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The LSS protein also known as lanosterol synthase plays a mechanical role in the biosynthesis of sterols. Its main function involves the cyclization of 23-oxidosqualene to lanosterol. LSS has a molecular weight of approximately 83 kDa. It is expressed widely across various tissues with notable presence in the liver adrenal glands and reproductive organs. This enzyme resides within the endoplasmic reticulum membrane reflecting its involvement in cholesterol synthesis.

Biological function summary

LSS catalyzes an important step in the conversion of squalene a precursor to the steroid skeleton into lanosterol. This function places LSS as an important contributor in the cholesterol biosynthesis pathway. LSS forms part of the sterol biosynthesis complex interacting with other enzymes to facilitate the production of essential sterols. By producing lanosterol LSS acts as a precursor gateway for other steroid hormones and molecules.

Pathways

Cholesterol homeostasis and steroidogenesis heavily depend on LSS activity. The enzyme operates within the mevalonate pathway an important cholesterol-producing route and is essential for the synthesis of isoprenoids. It interacts closely with HMG-CoA reductase an important regulator of cholesterol levels highlighting its central role in maintaining cellular lipid balance. Through its enzymatic action LSS links the synthesis of cholesterol with downstream steroid hormones.

Associated diseases and disorders

LSS has associations with conditions such as lathosterolosis a rare autosomal recessive disorder affecting cholesterol biosynthesis. Mutations in the LSS gene disrupt normal cholesterol production contributing to developmental abnormalities. Additionally LSS has connections to hypercholesterolemia having indirect relations through the cholesterol metabolism pathway which also involves the LDL receptor. These dysfunctions highlight the importance of LSS in maintaining systemic lipid homeostasis.