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AB89568

Anti-LTB antibody [MM0462-3J26]

5

(2 Reviews)

|

(2 Publications)

Mouse Monoclonal LTB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LTB.

View Alternative Names

TNFC, TNFSF3, LTB, Lymphotoxin-beta, LT-beta, Tumor necrosis factor C, Tumor necrosis factor ligand superfamily member 3, TNF-C

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0462-3J26

Isotype

IgG2

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LTB.

Q06643

Specificity

ab89568 detects Lymphotoxin Beta.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LTB also known as Lymphotoxin Beta is a member of the TNF (tumor necrosis factor) superfamily. Its molecular weight is approximately 33 kDa. LTB is expressed mainly in lymphoid tissues particularly in the spleen and thymus. This protein exists as a membrane-bound homotrimer or heterotrimer with Lymphotoxin Alpha influencing cellular processes both as individual units and in complex structures.
Biological function summary

LTB contributes to the formation and maintenance of secondary lymphoid tissues. LTB forms a complex with Lymphotoxin Alpha in a heterotrimeric arrangement which links it to immune responses by managing lymphoid organogenesis. It participates in regulating inflammation and maintaining organized lymphoid architecture impacting germinal center formation in response to antigenic stimulation.

Pathways

LTB plays a significant role in the NF-kB signaling pathway and lymphoid tissue organization. It interacts with the NF-kB pathway by engaging lymphotoxin-beta receptor (LTBR) leading to the activation of transcription factors. This interaction is vital in ensuring the proper migration and positioning of leukocytes associating LTB closely with proteins like LTBR and Rel proteins.

LTB demonstrates a significant link to autoimmune diseases and lymphomas. Its overexpression can contribute to chronic inflammatory conditions and certain types of B-cell lymphomas often through dysregulation of the NF-kB signaling pathway. In these conditions LTB interacts closely with associated molecules like LTBR and potentially with other TNF family members indicating its influence in pathological inflammatory pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cytokine that binds to LTBR/TNFRSF3 (PubMed : 24248355). May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
See full target information LTB
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 29:145 PubMed37884883

2023

Leveraging a disulfidptosis-related signature to predict the prognosis and immunotherapy effectiveness of cutaneous melanoma based on machine learning.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Zhao,Yanjun Wei,Lingjia Fan,Yuanliu Nie,Jianan Li,Renya Zeng,Jixian Li,Xiang Zhan,Lingli Lei,Zhichao Kang,Jiaxin Li,Wentao Zhang,Zhe Yang

Clinical & experimental ophthalmology 50:632-652 PubMed35322530

2022

Proprotein convertase furin is a driver and potential therapeutic target in proliferative diabetic retinopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Ahmed M Abu El-Asrar,Mohd I Nawaz,Ajmal Ahmad,Mohammad M Siddiquei,Eef Allegaert,Priscilla W Gikandi,Gert De Hertogh,Ghislain Opdenakker
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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