Rabbit Polyclonal LTBP2 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Latent-transforming growth factor beta-binding protein 2 aa 200-400.
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- Experimental and therapeutic medicine 22:11462021Latent-transforming growth factor β-binding protein 2 accelerates cardiac fibroblast apoptosis by regulating the expression and activity of caspase-3.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChunlai Shi,Xuan Li,Fei Hong,Xueyan Wang,Tingting Jiang,Bingbing Sun,Shuang LiPubMed 34504591
- Biochimica et biophysica acta. Molecular basis of disease 1866:1656302019High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMonica R Langley,Hyesook Yoon,Ha Neui Kim,Chan-Il Choi,Whitney Simon,Laurel Kleppe,Ian R Lanza,Nathan K LeBrasseur,Aleksey Matveyenko,Isobel A ScarisbrickPubMed 31816440
- Medicine 98:e172162019Expression and clinical significance of latent-transforming growth factor beta-binding protein 2 in primary hepatocellular carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJinchun Chen,Guosheng Gao,Hui Wang,Xingtao Ye,Jun Zhou,Jianjun LinPubMed 31574831
- Disease markers 2019:52312692019High Expression of LTBP2 Contributes to Poor Prognosis in Colorectal Cancer Patients and Correlates with the Mesenchymal Colorectal Cancer Subtype.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing Huang,Guihua Wang,Chunmei Zhao,Rong Geng,Shu Zhang,Wei Wang,Jing Chen,Huimin Liu,Xudong WangPubMed 30956730
- International journal of oncology 52:1886-18982018LTBP2 promotes the migration and invasion of gastric cancer cells and predicts poor outcome of patients with gastric cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJun Wang et. al.PubMed 29620158
- Medical science monitor : international medical jo 23:3232-32392017Latent Transforming Growth Factor β Binding Protein 2 (LTBP2) as a Novel Biomarker for the Diagnosis and Prognosis of Pancreatic Carcinoma.
- Disease markers 2017:61364012017CACNA1B (Ca2.2) Overexpression and Its Association with Clinicopathologic Characteristics and Unfavorable Prognosis in Non-Small Cell Lung Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoyu Zhou et. al.PubMed 28127114
- Oncotarget 7:45052-450592016LTBP2 is a prognostic marker in head and neck squamous cell carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLiang Han,Ming Ming Tang,Xinjiang Xu,Bin Jiang,Jianfei Huang,Xingmei Feng,Jianfeng QiangPubMed 27281608
- Biochimica et biophysica acta 1862:545-5552016Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHyesook Yoon et. al.PubMed 26826016
- FASEB journal : official publication of the Federa 29:4956-672015Extracellular matrix-induced Hic-5 expression in glomerular mesangial cells leads to a prosclerotic phenotype independent of TGF-β.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNick Hornigold et. al.PubMed 26405299
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human Latent-transforming growth factor beta-binding protein 2 aa 200-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q14767
Reactivity data
Select an application| IHC-P | ICC | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
Target data
Function
May play an integral structural role in elastic-fiber architectural organization and/or assembly.
Alternative names
C14orf141, LTBP3, LTBP2, C14orf141, LTBP3, Latent-transforming growth factor beta-binding protein 2, LTBP-2
Recommended products
Rabbit Polyclonal LTBP2 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Latent-transforming growth factor beta-binding protein 2 aa 200-400.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human Latent-transforming growth factor beta-binding protein 2 aa 200-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q14767
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LTBP2 also known as latent transforming growth factor-beta binding protein 2 is a glycoprotein involved in the regulation of transforming growth factor-beta (TGF-β) signaling. This protein has a mass of approximately 195 kDa. LTBP2 is expressed in a variety of tissues including the lungs heart and eyes. It plays an important role in the extracellular matrix where it is fundamental to the sequestration and subsequent activation of TGF-β.
- Biological function summary
LTBP2 interacts with the extracellular matrix components and acts as a structural protein. LTBP2 is an important part of TGF-β complexes. By anchoring TGF-β in a latent form it controls the availability and activation of TGF-β which is necessary for processes like cell growth differentiation and tissue repair. Without LTBP2 the controlled release of TGF-β can be disrupted impacting various cell functions.
- Pathways
LTBP2 regulates the TGF-β signaling pathway and maintains its equilibrium. This regulatory function links LTBP2 to the pathways involving cell proliferation and differentiation. LTBP2 closely interacts with other members of the LTBP family as well as proteins like fibrillin which are involved in the structural integrity of the extracellular matrix. These interactions are significant for maintaining proper signal transduction and cellular responses.
- Associated diseases and disorders
LTBP2 mutations have associations with conditions such as glaucoma and Weill-Marchesani syndrome. In glaucoma abnormalities in LTBP2 might affect the integrity of the extracellular matrix influencing intraocular pressure regulation. It also connects to fibrillin-related disorders due to its interaction with fibrillin proteins. These associations highlight the importance of LTBP2 in both structural and signaling roles within the body.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunocytochemistry - Anti-LTBP2 antibody (ab121193)
Immunocytochemistry analysis of U-2 OS (human bone osteosarcoma epithelial cell line) cells labelling MLTBP2 with ab121193 at 2 μg/mL.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LTBP2 antibody (ab121193)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling MLTBP2 with ab121193 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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