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AB171241

Anti-LTBR antibody [3C8] - Low endotoxin, Azide free

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(1 Publication)

Rat Monoclonal LTBR antibody. Carrier free. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication.

View Alternative Names

Tnfcr, Tnfrsf3, Ltbr, Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor

1 Images
Flow Cytometry - Anti-LTBR antibody [3C8] - Low endotoxin, Azide free (AB171241)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-LTBR antibody [3C8] - Low endotoxin, Azide free (AB171241)

Flow cytometry analysis of total viable NIH/3T3 cells (10e5 to 10e8) labeling LTBR with ab171241 (filled histogram) at 0.25μg or Rat IgG1 control (open histogram). Followed by anti-Rat IgG Biotin and Streptavidin PE.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

3C8

Isotype

IgG1

Light chain type

kappa

Carrier free

Yes

Reacts with

Mouse

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>ab171241 can be used at less than or equal to 0.5μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10e5 to 10e8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.</p><p><a href='/en-us/products/unavailable/rat-igg1-kappa-rtk2071-isotype-control-low-endotoxin-azide-free-ab18407'>ab18407</a> - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }
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Product details

Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by the LAL assay.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.2 Constituents: 100% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LTBR (lymphotoxin beta receptor) also known as the TNFRSF3 is a significant protein that functions as a receptor for lymphotoxin and other related cytokines. The protein has a mass of around 62 kDa and is expressed in various tissues including lymphoid tissues and the epithelial cells of several organs. LTBR is present as a membrane-bound protein and helps mediate signaling that is important for cellular communication and function. Key interactions with ligands such as LTA and LIGHT activate signaling pathways which play roles in immune response.
Biological function summary

LTBR coordinates multiple cellular processes especially in immune regulation and homeostasis. It forms a complex with cytokines that binds to its extracellular domain triggering downstream signaling cascades. These cascades lead to activation of nuclear factor kappa B (NF-kB) which controls gene transcription and promotes survival and differentiation of immune cells. The capability of LTBR to interact with other TNF receptors expands its influence in lymphoid organogenesis and maintenance especially in maintaining the integrity of the lymphoid system.

Pathways

LTBR significantly participates in both the NF-kB and the non-canonical NF-kB pathways. These pathways are essential for regulating immune response and inflammation. Within these pathways LTBR interacts with other proteins such as TRAF3 and TRAF2 to mediate signaling processes. This arrangement allows for modulation of immune responses and is critical for recognizing and eliminating pathogens. Additionally the involvement of LTBR in immune system pathways aligns it with the functions of closely related proteins like TNF receptor superfamily members.

LTBR has been implicated in autoimmune diseases and cancer. In autoimmunity aberrant signaling through LTBR may lead to inappropriate immune responses and inflammation as seen in disorders like systemic lupus erythematosus. Moreover in oncology abnormalities in LTBR signaling can influence tumor microenvironments and support tumor cell survival. Throughout these disease contexts LTBR often interacts with other risk-associated proteins such as NFKB1 highlighting its integration in complex pathological processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Activates NF-kappa-B signaling upon stimulation with lymphotoxin. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.. (Microbial infection) Plays a role in host defense against Zika virus infection.
See full target information Ltbr
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature cell biology 17:665-77 PubMed25915125

2015

The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development.

Applications

Unspecified application

Species

Unspecified reactive species

Xunlei Kang,Zhigang Lu,Changhao Cui,Mi Deng,Yuqi Fan,Baijun Dong,Xin Han,Fuchun Xie,Jeffrey W Tyner,John E Coligan,Robert H Collins,Xiangshu Xiao,M James You,Cheng Cheng Zhang
View all publications
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