AB65089

Anti-LTBR antibody [5G11]

Name: Anti-LTBR antibody [5G11] (ab65089) | Abcam
Brand: Abcam Limited
SKU: AB65089
Price: 430 USD
Availability: InStock

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(10 Publications)

Rat Monoclonal LTBR antibody. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 10 publications. Immunogen corresponding to Recombinant Protein within Mouse Ltbr.

View Alternative Names

Tnfcr, Tnfrsf3, Ltbr, Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor

1 Images

Flow Cytometry - Anti-LTBR antibody [5G11] (AB65089)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-LTBR antibody [5G11] (AB65089)

Detection of LT beta receptor in Wehi-167 cells. Red, black and blue line represent the isotype control, cells only and ab65089 at 10 μg/ml, respectively.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

5G11

Isotype

IgG2a

Carrier free

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Recombinant Protein within Mouse Ltbr. The exact immunogen used to generate this antibody is proprietary information.

P50284

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/50", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/rat-igg2a-kappa-monoclonal-rtk2758-isotype-control-ab18450'>ab18450</a> - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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Product details

This antibody is an agonist of LTBR in vitro and is provided in a low endotoxin format.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

ab65089 was 0.2µm filtered.

Storage buffer

Constituents: PBS, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LTBR (lymphotoxin beta receptor) also known as the TNFRSF3 is a significant protein that functions as a receptor for lymphotoxin and other related cytokines. The protein has a mass of around 62 kDa and is expressed in various tissues including lymphoid tissues and the epithelial cells of several organs. LTBR is present as a membrane-bound protein and helps mediate signaling that is important for cellular communication and function. Key interactions with ligands such as LTA and LIGHT activate signaling pathways which play roles in immune response.

Biological function summary

LTBR coordinates multiple cellular processes especially in immune regulation and homeostasis. It forms a complex with cytokines that binds to its extracellular domain triggering downstream signaling cascades. These cascades lead to activation of nuclear factor kappa B (NF-kB) which controls gene transcription and promotes survival and differentiation of immune cells. The capability of LTBR to interact with other TNF receptors expands its influence in lymphoid organogenesis and maintenance especially in maintaining the integrity of the lymphoid system.

Pathways

LTBR significantly participates in both the NF-kB and the non-canonical NF-kB pathways. These pathways are essential for regulating immune response and inflammation. Within these pathways LTBR interacts with other proteins such as TRAF3 and TRAF2 to mediate signaling processes. This arrangement allows for modulation of immune responses and is critical for recognizing and eliminating pathogens. Additionally the involvement of LTBR in immune system pathways aligns it with the functions of closely related proteins like TNF receptor superfamily members.

LTBR has been implicated in autoimmune diseases and cancer. In autoimmunity aberrant signaling through LTBR may lead to inappropriate immune responses and inflammation as seen in disorders like systemic lupus erythematosus. Moreover in oncology abnormalities in LTBR signaling can influence tumor microenvironments and support tumor cell survival. Throughout these disease contexts LTBR often interacts with other risk-associated proteins such as NFKB1 highlighting its integration in complex pathological processes.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Activates NF-kappa-B signaling upon stimulation with lymphotoxin. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.. (Microbial infection) Plays a role in host defense against Zika virus infection.

See full target information Ltbr

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

The Journal of pathology 259:236-253 PubMed36367235

2022

Stromal transdifferentiation drives lipomatosis and induces extensive vascular remodeling in the aging human lymph node.

Applications

Unspecified application

Species

Unspecified reactive species

Tove Bekkhus,Anna Olofsson,Ying Sun,Peetra U Magnusson,Maria H Ulvmar

Cancer cell international 21:118 PubMed33602223

2021

LncRNA HOXA-AS3 promotes gastric cancer progression by regulating miR-29a-3p/LTβR and activating NF-κB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Qu,Bin Zhu,Yi-Lin Hu,Qin-Sheng Mao,Ying Feng

Nature communications 11:519 PubMed31980640

2020

YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sung Yong Choi,Hosung Bae,Sun-Hye Jeong,Intae Park,Hyunsoo Cho,Seon Pyo Hong,Da-Hye Lee,Choong-Kun Lee,Jin-Sung Park,Sang Heon Suh,Jeongwoon Choi,Myung Jin Yang,Jeon Yeob Jang,Lucas Onder,Jeong Hwan Moon,Han-Sin Jeong,Ralf H Adams,Jin-Man Kim,Burkhard Ludewig,Joo-Hye Song,Dae-Sik Lim,Gou Young Koh

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 7:1901261 PubMed31921549

2020

TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Meixin Chen,Zhiyao Zhao,Qingcai Meng,Puping Liang,Zexiong Su,Yaoxing Wu,Junjiu Huang,Jun Cui

Immunology 155:505-518 PubMed30144045

2018

mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity.

Applications

Unspecified application

Species

Unspecified reactive species

Naresh Kumar Meena,Shakti Prasad Pattanayak,Yael Ben-Nun,Sandrine Benhamron,Saran Kumar,Emmanuelle Merquiol,Nadine Hövelmeyer,Galia Blum,Boaz Tirosh

PLoS biology 16:e2004663 PubMed29889904

2018

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Zhao,Lei Zhang,Xiaodong Mu,Christelle Doebelin,William Nguyen,Callen Wallace,Daniel P Reay,Sara J McGowan,Lana Corbo,Paula R Clemens,Gabriela Mustata Wilson,Simon C Watkins,Laura A Solt,Michael D Cameron,Johnny Huard,Laura J Niedernhofer,Theodore M Kamenecka,Paul D Robbins

Science translational medicine 9: PubMed28404866

2017

Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth Allen,Arnaud Jabouille,Lee B Rivera,Inge Lodewijckx,Rindert Missiaen,Veronica Steri,Kevin Feyen,Jaime Tawney,Douglas Hanahan,Iacovos P Michael,Gabriele Bergers

Science signaling 7:ra13 PubMed24497610

2014

Noncanonical NF-κB signaling is limited by classical NF-κB activity.

Applications

Unspecified application

Species

Unspecified reactive species

Carolyn M Gray,Caroline Remouchamps,Kelly A McCorkell,Laura A Solt,Emmanuel Dejardin,Jordan S Orange,Michael J May

European cytokine network 14:103-7 PubMed12957791

2003

Activation of the lymphotoxin-beta receptor induces NFkappaB-dependent interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas Hehlgans,Peter Müller,Peter Stopfer,Daniela N Männel

European journal of cell biology 73:368-77 PubMed9270880

1997

Characterization of MEC 14.7, a new monoclonal antibody recognizing mouse CD34: a useful reage for identifying and characterizing blood vessels and hematopoietic precursors.

Applications

Unspecified application

Species

Unspecified reactive species

C Garlanda,R Berthier,J Garin,A Stoppacciaro,L Ruco,D Vittet,D Gulino,C Matteucci,A Mantovani,A Vecchi,E Dejana

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-LTBR antibody [5G11]

Flow Cytometry - Anti-LTBR antibody [5G11] (AB65089)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (10)

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