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AB70063

Anti-LTBR antibody

3

(2 Reviews)

|

(8 Publications)

Rabbit Polyclonal LTBR antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human LTBR.

View Alternative Names

D12S370, TNFCR, TNFR3, TNFRSF3, LTBR, Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor type III, TNF-RIII, TNFR-III

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-LTBR antibody (AB70063)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-LTBR antibody (AB70063)

HeLa cells with ab70063 at 1/500 dilution, with and without the immunising peptide.

Western blot - Anti-LTBR antibody (AB70063)
  • WB

Unknown

Western blot - Anti-LTBR antibody (AB70063)

All lanes:

Western blot - Anti-LTBR antibody (ab70063) at 1/500 dilution

Lane 1:

HeLa cell extract at 5 µg

Lane 2:

HepG2 cell extract at 5 µg

Lane 3:

HeLa cell extract at 5 µg with immunising peptide

Predicted band size: 47 kDa

Observed band size: 22 kDa,50 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human LTBR. The exact immunogen used to generate this antibody is proprietary information.

P36941

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LTBR (lymphotoxin beta receptor) also known as the TNFRSF3 is a significant protein that functions as a receptor for lymphotoxin and other related cytokines. The protein has a mass of around 62 kDa and is expressed in various tissues including lymphoid tissues and the epithelial cells of several organs. LTBR is present as a membrane-bound protein and helps mediate signaling that is important for cellular communication and function. Key interactions with ligands such as LTA and LIGHT activate signaling pathways which play roles in immune response.
Biological function summary

LTBR coordinates multiple cellular processes especially in immune regulation and homeostasis. It forms a complex with cytokines that binds to its extracellular domain triggering downstream signaling cascades. These cascades lead to activation of nuclear factor kappa B (NF-kB) which controls gene transcription and promotes survival and differentiation of immune cells. The capability of LTBR to interact with other TNF receptors expands its influence in lymphoid organogenesis and maintenance especially in maintaining the integrity of the lymphoid system.

Pathways

LTBR significantly participates in both the NF-kB and the non-canonical NF-kB pathways. These pathways are essential for regulating immune response and inflammation. Within these pathways LTBR interacts with other proteins such as TRAF3 and TRAF2 to mediate signaling processes. This arrangement allows for modulation of immune responses and is critical for recognizing and eliminating pathogens. Additionally the involvement of LTBR in immune system pathways aligns it with the functions of closely related proteins like TNF receptor superfamily members.

LTBR has been implicated in autoimmune diseases and cancer. In autoimmunity aberrant signaling through LTBR may lead to inappropriate immune responses and inflammation as seen in disorders like systemic lupus erythematosus. Moreover in oncology abnormalities in LTBR signaling can influence tumor microenvironments and support tumor cell survival. Throughout these disease contexts LTBR often interacts with other risk-associated proteins such as NFKB1 highlighting its integration in complex pathological processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT (PubMed : 24248355). Activates NF-kappa-B signaling pathway upon stimulation with lymphotoxin (LTA(1)-LTB(2)) (PubMed : 24248355). Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
See full target information LTBR
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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

PeerJ 11:e15551 PubMed37366426

2023

Silencing of TRAF5 enhances necroptosis in hepatocellular carcinoma by inhibiting LTBR-mediated NF-κB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Guolin Wu,Fangping Wu,Yang Qing Zhou,Wenwen Lu,Feng Lin Hu,Xiaofen Fan

Proceedings of the National Academy of Sciences of the United States of America 119:e2208274119 PubMed36383602

2022

Interference with LTβR signaling by tick saliva facilitates transmission of Lyme disease spirochetes.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Jin,Bao-Gui Jiang,Yizhu Yin,Jingya Guo,Jia-Fu Jiang,Xiaopeng Qi,Gary Crispell,Shahid Karim,Wu-Chun Cao,Ren Lai

Computational and mathematical methods in medicine 2022:9588740 PubMed36118831

2022

CREB1 Transcriptionally Activates LTBR to Promote the NF-B Pathway and Apoptosis in Lung Epithelial Cells.

Applications

WB

Species

Human

Zhengyun Hu,Guoping Zhou

Frontiers in cell and developmental biology 9:721543 PubMed34676210

2021

Stimulation of Non-canonical NF-κB Through Lymphotoxin-β-Receptor Impairs Myogenic Differentiation and Regeneration of Skeletal Muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Manuel Schmidt,Anja Weidemann,Christine Poser,Anne Bigot,Julia von Maltzahn

Annals of palliative medicine 9:805-815 PubMed32279515

2020

Lymphotoxin beta receptor is associated with regulation of microRNAs expression and nuclear factor-kappa B activation in lipopolysaccharides (LPS)-stimulated vascular smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Ling,Mei Wen,Zezhou Xiao,Zhiwen Luo,Jiawei Zhuang,Qianqin Li,Songlin Du,Shaoyi Zheng,Peng Zhu

Nature communications 11:519 PubMed31980640

2020

YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sung Yong Choi,Hosung Bae,Sun-Hye Jeong,Intae Park,Hyunsoo Cho,Seon Pyo Hong,Da-Hye Lee,Choong-Kun Lee,Jin-Sung Park,Sang Heon Suh,Jeongwoon Choi,Myung Jin Yang,Jeon Yeob Jang,Lucas Onder,Jeong Hwan Moon,Han-Sin Jeong,Ralf H Adams,Jin-Man Kim,Burkhard Ludewig,Joo-Hye Song,Dae-Sik Lim,Gou Young Koh

The American journal of pathology 190:252-269 PubMed31585070

2019

Host Lymphotoxin-β Receptor Signaling Is Crucial for Angiogenesis of Metanephric Tissue Transplanted into Lymphoid Sites.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Giovanna Francipane,Bing Han,Eric Lagasse

Molecular medicine reports 11:783-90 PubMed25369740

2014

Lymphotoxin β receptor activation promotes bladder cancer in a nuclear factor-κB-dependent manner.

Applications

IHC-P

Species

Human

Mo Shen,Xiuzhi Duan,Ping Zhou,Wu Zhou,Xiuling Wu,Siqi Xu,Yuhua Chen,Zhihua Tao
View all publications
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Product promise

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