Rabbit Polyclonal Lubricin/MSF antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse, African green monkey samples. Cited in 59 publications. Immunogen corresponding to Synthetic Peptide within Human PRG4 aa 1350-1400.
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- Nature communications 14:69092023Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJia Q Ng,Toghrul H Jafarov,Christopher B Little,Tongtong Wang,Abdullah M Ali,Yan Ma,Georgette A Radford,Laura Vrbanac,Mari Ichinose,Samuel Whittle,David J Hunter,Tamsin R M Lannagan,Nobumi Suzuki,Jarrad M Goyne,Hiroki Kobayashi,Timothy C Wang,David R Haynes,Danijela Menicanin,Stan Gronthos,Daniel L Worthley,Susan L Woods,Siddhartha MukherjeePubMed 37907525
- Journal of cellular physiology 238:2668-26782023Loss of miR-204 and miR-211 shifts osteochondral balance and causes temporomandibular joint osteoarthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJian Huang,Yumei Lai,Jun Li,Lan ZhaoPubMed 37697972
- Biomedicines 11:2023Evaluation of Cartilage Integrity Following Administration of Oral and Intraarticular Nifedipine in a Murine Model of Osteoarthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesViktorija Aleksiuk,Justinas Baleisis,Gailute Kirdaite,Ilona Uzieliene,Jaroslav Denkovskij,Paulius Bernotas,Tatjana Ivaskiene,Ali Mobasheri,Eiva BernotienePubMed 37760884
- PloS one 18:e02800242023Directed differentiation of hPSCs through a simplified lateral plate mesoderm protocol for generation of articular cartilage progenitors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChristopher A Smith,Paul A Humphreys,Mark A Naven,Steven Woods,Fabrizio E Mancini,Julieta O'Flaherty,Qing-Jun Meng,Susan J KimberPubMed 36706111
- Biomolecules 13:2023Silencing Protects against Injury-Induced Osteoarthritis in Mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaocheng Qin,Cuicui Wang,Yonghua He,Aiwu Lu,Tiandao Li,Bo Zhang,Jie ShenPubMed 36671508
- Bone reports 18:1016532023Role of cartilage and bone matrix regulation in early equine osteochondrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesS K Grissom,S A Semevolos,K Duesterdieck-ZellmerPubMed 36632355
- Nature communications 13:61872022Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKosei Nagata,Hironori Hojo,Song Ho Chang,Hiroyuki Okada,Fumiko Yano,Ryota Chijimatsu,Yasunori Omata,Daisuke Mori,Yuma Makii,Manabu Kawata,Taizo Kaneko,Yasuhide Iwanaga,Hideki Nakamoto,Yuji Maenohara,Naohiro Tachibana,Hisatoshi Ishikura,Junya Higuchi,Yuki Taniguchi,Shinsuke Ohba,Ung-Il Chung,Sakae Tanaka,Taku SaitoPubMed 36261443
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 37:2498-25112022Activating EGFR Signaling Attenuates Osteoarthritis Development Following Loading Injury in Mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTao Gui,Yulong Wei,Lijun Luo,Jun Li,Leilei Zhong,Lutian Yao,Frank Beier,Charles L Nelson,Andrew Tsourkas,X Sherry Liu,Motomi Enomoto-Iwamoto,Feifan Yu,Zhiliang Cheng,Ling QinPubMed 36178273
- Genome medicine 14:782022Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarietta Armaka,Dimitris Konstantopoulos,Christos Tzaferis,Matthieu D Lavigne,Maria Sakkou,Anastasios Liakos,Petros P Sfikakis,Meletios A Dimopoulos,Maria Fousteri,George KolliasPubMed 35879783
- Cell reports 39:1107622022A Cd9Cd271 stem/progenitor population and the SHP2 pathway contribute to neonatal-to-adult switching that regulates tendon maturation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChunmei Fan,Yanyan Zhao,Yangwu Chen,Tian Qin,Junxin Lin,Shan Han,Ruojin Yan,Tingyun Lei,Yuanhao Xie,Tingzhang Wang,Shen Gu,Hongwei Ouyang,Weiliang Shen,Zi Yin,Xiao ChenPubMed 35476985
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: PBS, 0.1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human PRG4 aa 1350-1400. The exact immunogen used to generate this antibody is proprietary information. Database link Q92954
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Expected | Expected |
| Mouse | Predicted | Expected | Expected |
| African green monkey | Predicted | Expected | Expected |
| Horse | Predicted | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 2 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Horse, Mouse, African green monkey | Dilution info - | Notes - |
IHC-P
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, African green monkey, Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Horse | Dilution info - | Notes - |
ICC/IF
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, African green monkey, Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Horse | Dilution info - | Notes - |
Associated Products
Select an associated product type
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Target data
Function
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.
Alternative names
MSF, SZP, PRG4, Proteoglycan 4, Lubricin, Megakaryocyte-stimulating factor, Superficial zone proteoglycan
Recommended products
Rabbit Polyclonal Lubricin/MSF antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse, African green monkey samples. Cited in 59 publications. Immunogen corresponding to Synthetic Peptide within Human PRG4 aa 1350-1400.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: PBS, 0.1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human PRG4 aa 1350-1400. The exact immunogen used to generate this antibody is proprietary information. Database link Q92954
- Purification technique
- Affinity purification Immunogen
- Specificity
ab28484 recognises Lubricin/MSF.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Western blot - Anti-Lubricin/MSF antibody (ab28484)
Primary antibody was diluted in antibody diluent using a Fast Western Blot kit and followed by the optimized HRP reagent. Chemiluminescent detection was performed using SuperSignal West Dura.
All lanes: Western blot - Anti-Lubricin/MSF antibody (ab28484) at 2 µg/mL
All lanes: non-reduced human synovial fluid at 3 µg
Predicted band size: 151 kDa
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