JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB201098

Anti-LY6E/SCA-2 antibody

1

(2 Reviews)

|

(3 Publications)

Rabbit Polyclonal LY6E/SCA-2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human LY6E aa 1-100.

View Alternative Names

9804, RIGE, SCA2, TSA1, LY6E, Lymphocyte antigen 6E, Ly-6E, Retinoic acid-induced gene E protein, Stem cell antigen 2, Thymic shared antigen 1, RIG-E, SCA-2, TSA-1

1 Images
Western blot - Anti-LY6E/SCA-2 antibody (AB201098)
  • WB

Supplier Data

Western blot - Anti-LY6E/SCA-2 antibody (AB201098)

All lanes:

Western blot - Anti-LY6E/SCA-2 antibody (ab201098)

Lane 1:

HEK-293T whole cell lysate

Lane 2:

Raw264.7 whole cell lysate

Lane 3:

H9C2 whole cell lysate

Predicted band size: 14 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human LY6E aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q16553

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purity is > 95% by SDS-PAGE.
Storage buffer
pH: 7.3 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LY6E also known as SCA-2 is a membrane protein known for its role in immune response. With a mass of approximately 15 kDa LY6E is expressed on the cell surface in various tissues including the immune system and some epithelial cells. The protein belongs to the LY6 family which is characterized by the presence of a Ly6/uPAR domain playing a part in cellular signaling and host defense mechanisms.
Biological function summary

LY6E has a significant impact on immune modulation and viral infection processes. It interacts with other immune-related proteins and contributes to the regulation of T-cell proliferation and differentiation. While LY6E is not a part of a multi-protein complex itself its activity can modify the function of immune cells and potentially alter immune responses. This makes it an important player in the context of both adaptive and innate immunity.

Pathways

LY6E participates in key immune signaling pathways particularly those related to interferon signaling and antiviral defense. It influences these pathways by interacting with components such as interferon-gamma and other cytokines which regulate immune cell behavior and response. LY6E affects the STAT pathway by indirectly modulating the activity of STAT1 a critical protein in immune response highlighting its importance in orchestrating immune dynamics.

LY6E has been implicated in several viral infections and cancers. Its expression alters during viral infections such as influenza and HIV where it may play a role in enhancing or suppressing viral replication. LY6E's interaction with other proteins like STAT1 and various viral envelope proteins could contribute to immune escape or disease progression. Moreover aberrant regulation of LY6E levels has connections with cancer progression affecting tumor immunity and potentially making it a target for therapeutic interventions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed : 32641482). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity).. (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus (PubMed : 28130445). In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E (PubMed : 28130445, PubMed : 29610346). Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape (PubMed : 28130445, PubMed : 30190477).
See full target information LY6E
style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:20196 PubMed39215036

2024

Lymphocyte antigen 6 family member E suppresses apoptosis and promotes pancreatic cancer growth and migration via Wnt/β-catenin pathway activation.

Applications

Unspecified application

Species

Unspecified reactive species

Kenan Cen,Jingyao Zhou,Xuejia Yang,Yangyang Guo,Yanyi Xiao

Experimental and therapeutic medicine 22:1247 PubMed34539843

2021

LINC00473 exacerbates osteoarthritis development by promoting chondrocyte apoptosis and proinflammatory cytokine production through the miR-424-5p/LY6E axis.

Applications

Unspecified application

Species

Unspecified reactive species

Guiyong Fan,Jinlian Liu,Yesong Zhang,Xinxian Guan

Frontiers in microbiology 10:130 PubMed30787914

2019

Transcriptome Sequencing Identifies Novel Immune Response Genes Highly Related to the Severity of Human Adenovirus Type 55 Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Xu,Zhe Xu,Lei Huang,En-Qiang Qin,Jie-Li Zhang,Peng Zhao,Bo Tu,Lei Shi,Wen-Gang Li,Wei-Wei Chen
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB172021

Anti-LY6E/SCA-2 antibody

Western blot - Anti-LY6E/SCA-2 antibody (AB172021)

  • 0
  • 0

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB92547

Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Multiplex immunohistochemistry - Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker (AB92547)

  • 5
  • 92
Primary Antibodies

AB263947

Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-STAT6 (phospho Y641) antibody [EPR22599-78] (AB263947)

  • 5
  • 1
Primary Antibodies

AB214486

Anti-Annexin A1/ANXA1 antibody [EPR19342]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Annexin A1/ANXA1 antibody [EPR19342] (AB214486)

  • 5
  • 12

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com