Rabbit Polyclonal LY6G5C antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LY6G5C.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
May have a role in hematopoietic cell differentiation.
C6orf20, G5C, NG33, LY6G5C, Lymphocyte antigen 6 complex locus protein G5c
Rabbit Polyclonal LY6G5C antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LY6G5C.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
LY6G5C also known as lymphocyte antigen 6 complex locus G5C is a protein that plays a role in immune function. LY6G5C has a molecular mass of approximately 25 kDa. It is expressed on the surface of hematopoietic cells including various immune cell types which points to its importance in the immune system. The expression in these cells suggests the involvement of LY6G5C in cellular interactions and signaling processes.
LY6G5C participates in the modulation of immune responses possibly by affecting cell-cell communications. It is part of the Ly6 family known for their roles in cell adhesion and signaling. The protein does not typically form complexes on its own but interacts with different cell surface receptors to execute its functions. The study of LY6G5C has shown its potential involvement in the regulation of neutrophil activity and differentiation.
LY6G5C engages in the signaling pathways that regulate immune responses. It interacts with proteins like CD11b and CD18 which are integrins involved in leukocyte adhesion and migration. These associations place LY6G5C in the integrin-mediated signaling pathway. The protein's interaction with these integrins hints at a function in facilitating neutrophil recruitment to inflamed tissues an essential part of the immune response.
LY6G5C has links to certain autoimmune conditions and inflammatory diseases. For instance its altered expression or function might contribute to the pathogenesis of rheumatoid arthritis. In rheumatoid arthritis an overactive immune response damages joint tissues and proteins like CD11b that associate with LY6G5C also play a role. Understanding the connection between LY6G5C and these conditions can provide insights into potential therapeutic targets.
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Immunohistochemical staining of human colon tissue targetting LY6G5C using 1/100 ab122501.
Immunofluorescent staining of Human cell line U-251 MG shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab122501 1-4 µg/ml. Cells treated with PFA/Triton X-100.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human tonsil tissue labelling LY6G5C with ab122501 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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