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AB122501

Anti-LY6G5C antibody

4

(1 Review)

|

(2 Publications)

Rabbit Polyclonal LY6G5C antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LY6G5C.

View Alternative Names

C6orf20, G5C, NG33, LY6G5C, Lymphocyte antigen 6 complex locus protein G5c

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LY6G5C antibody (AB122501)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LY6G5C antibody (AB122501)

Immunohistochemical staining of human colon tissue targetting LY6G5C using 1/100 ab122501.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LY6G5C antibody (AB122501)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LY6G5C antibody (AB122501)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human tonsil tissue labelling LY6G5C with ab122501 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunocytochemistry/ Immunofluorescence - Anti-LY6G5C antibody (AB122501)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-LY6G5C antibody (AB122501)

Immunofluorescent staining of Human cell line U-251 MG shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab122501 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human LY6G5C. The exact immunogen used to generate this antibody is proprietary information.

Q5SRR4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LY6G5C also known as lymphocyte antigen 6 complex locus G5C is a protein that plays a role in immune function. LY6G5C has a molecular mass of approximately 25 kDa. It is expressed on the surface of hematopoietic cells including various immune cell types which points to its importance in the immune system. The expression in these cells suggests the involvement of LY6G5C in cellular interactions and signaling processes.
Biological function summary

LY6G5C participates in the modulation of immune responses possibly by affecting cell-cell communications. It is part of the Ly6 family known for their roles in cell adhesion and signaling. The protein does not typically form complexes on its own but interacts with different cell surface receptors to execute its functions. The study of LY6G5C has shown its potential involvement in the regulation of neutrophil activity and differentiation.

Pathways

LY6G5C engages in the signaling pathways that regulate immune responses. It interacts with proteins like CD11b and CD18 which are integrins involved in leukocyte adhesion and migration. These associations place LY6G5C in the integrin-mediated signaling pathway. The protein's interaction with these integrins hints at a function in facilitating neutrophil recruitment to inflamed tissues an essential part of the immune response.

LY6G5C has links to certain autoimmune conditions and inflammatory diseases. For instance its altered expression or function might contribute to the pathogenesis of rheumatoid arthritis. In rheumatoid arthritis an overactive immune response damages joint tissues and proteins like CD11b that associate with LY6G5C also play a role. Understanding the connection between LY6G5C and these conditions can provide insights into potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May have a role in hematopoietic cell differentiation.
See full target information LY6G5C
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 12:634115 PubMed34163351

2021

Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Shaorong Li,Hua Jin,Guangyong Sun,Chunmei Zhang,Jinsong Wang,Hufeng Xu,Dong Zhang,Songlin Wang

BMC cancer 15:559 PubMed26223354

2015

A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women.

Applications

Unspecified application

Species

Unspecified reactive species

Fangfang Song,Jun Zhang,Li Qiu,Yawen Zhao,Pan Xing,Jiachun Lu,Kexin Chen,Zheng Li
View all publications
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Product promise

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