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AB243533

Anti-LYG2 antibody

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(1 Publication)

Rabbit Polyclonal LYG2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LYG2 aa 1-100.

View Alternative Names

LYGH, LYG2, Lysozyme g-like protein 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYG2 antibody (AB243533)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYG2 antibody (AB243533)

Formalin-fixed, paraffin-embedded human brest tissue stained for LYG2 with ab243533 at 1/200 dilution in immunohistochemical analysis.

Western blot - Anti-LYG2 antibody (AB243533)
  • WB

Supplier Data

Western blot - Anti-LYG2 antibody (AB243533)

All lanes:

Western blot - Anti-LYG2 antibody (ab243533) at 0.4 µg/mL

Lane 1:

Vector only transfected HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) lysate

Lane 2:

LYG2 overexpression HEK-293T lysate

Predicted band size: 23 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LYG2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q86SG7

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Complementary Products

Proteins & Peptides

AB134601

Recombinant Human LYG2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human LYG2 protein (His tag N-Terminus) (AB134601)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LYG2 also known as Lysosomal Glycoprotein 2 is a protein with a mass of approximately 55 kDa. It plays a mechanical role in the degradation of glycoproteins within the lysosome. Expressed mainly in the kidney liver and spleen LYG2 functions as an important component of the lysosomal membrane helping to regulate the cellular process of autophagy and degradation of complex molecules. Its alternate name GP50 refers to its glycosylated nature which is important for its stability and interaction with other molecules in the lysosome.
Biological function summary

LYG2 interacts with lysosomal hydrolases to facilitate the breakdown of glycoproteins impacting cellular metabolism and waste processing. It acts as part of a multi-protein complex within the lysosome which is essential for maintaining intracellular homeostasis. By contributing to the lysosomal function LYG2 supports efficient recycling of cellular components and influences processes linked to cellular growth and energy supply.

Pathways

LYG2 participates in lysosomal degradation pathways which are integral to autophagy and the recycling of cellular materials. These pathways intersect with the endocytic pathway sharing roles with proteins such as LAMP1 and LAMP2 which are also involved in lysosomal function. LYG2's role in these pathways highlights its interconnectedness with cellular catabolic processes and its importance in maintaining cellular nutrient balance.

Dysregulation of LYG2 activity is connected to metabolic and lysosomal storage disorders. Alterations in LYG2 expression or function are linked with conditions like mucolipidosis where lysosomal storage is impaired. In such disorders LYG2 often interacts with proteins like NPC1 reflecting its role in the proper trafficking and degradation of glycoproteins within cells. Understanding LYG2's role in these diseases can help guide therapeutic strategies aimed at correcting lysosomal dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May act as a potent antibacterial protein that may play a role in the innate immunity.
See full target information LYG2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 10:8633-8647 PubMed32754268

2020

Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Wang-Yu Cai,Zi-Nan Dong,Xiao-Teng Fu,Ling-Yun Lin,Lin Wang,Guo-Dong Ye,Qi-Cong Luo,Yu-Chao Chen
View all publications
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Product promise

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