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AB229338

Anti-Lyl1 antibody - C-terminal

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(2 Publications)

Rabbit Polyclonal LYL1 antibody. C-terminal. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LYL1.

View Alternative Names

BHLHA18, LYL1, Protein lyl-1, Class A basic helix-loop-helix protein 18, Lymphoblastic leukemia-derived sequence 1, bHLHa18

1 Images
Western blot - Anti-Lyl1 antibody - C-terminal (AB229338)
  • WB

Supplier Data

Western blot - Anti-Lyl1 antibody - C-terminal (AB229338)

12% SDS-PAGE gel.

All lanes:

Western blot - Anti-Lyl1 antibody - C-terminal (ab229338) at 1/1000 dilution

All lanes:

K562 (human chronic myelogenous leukemia cell line from bone marrow) whole cell lysate at 30 µg

Predicted band size: 30 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human LYL1. The exact immunogen used to generate this antibody is proprietary information.

P12980

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Lyl1 also known as Lim domain only protein 1 is a transcription factor with a mass of approximately 14 kDa. It plays a critical role in gene expression regulation. Lyl1 is expressed in hematopoietic tissues particularly in the bone marrow and lymphoid organs. It is known for its involvement in the development of certain lineages of blood cells. As a member of the basic helix-loop-helix (bHLH) family Lyl1 closely relates to other transcription factors that influence cellular differentiation.
Biological function summary

Lyl1 influences various cellular processes including the transcriptional regulation of hematopoietic stem cells. The protein does not typically function as part of a larger complex but interacts with core transcription machinery to modulate gene expression. Lyl1 affects lineage commitment and is important for the development of several types of blood cells especially impacting progenitor cells. Its presence and activity impact how blood cells multiply and differentiate into mature forms.

Pathways

The function of Lyl1 integrates into the hematopoietic and immune system pathways. It interacts with other proteins like Tal1 and HEB which are also bHLH transcription factors involved in blood cell development. Within these pathways Lyl1 contributes to the regulation and maintenance of stem cells ensuring balanced lineage differentiation and functional diversity within the hematopoietic system.

Aberrations in Lyl1 expression or function can lead to various forms of leukemia especially acute lymphoblastic leukemia (ALL). Lyl1 involvement in leukemia often connects with other oncogenes and regulatory proteins such as Notch1 which participate in the development and progression of the disease. Another disease associated with Lyl1 is lymphoblastic lymphoma where it contributes to uncontrolled proliferation and survival of affected cells. Understanding the specific role of Lyl1 in these disorders aids in developing targeted therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information LYL1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular gastroenterology and hepatology 18:101348 PubMed38697356

2024

RASSF4 Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease Progression via Hippo Signaling and Suppresses Hepatocarcinogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Chaofei Xu,Ting Fang,Jingru Qu,Yahui Miao,Lei Tian,Man Zhang,Hao Zhuang,Bei Sun,Liming Chen

Scientific reports 12:7226 PubMed35508511

2022

The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshihiro Yamada,Yi Zhong,Shiho Miki,Akiko Taura,Terence H Rabbitts
View all publications
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