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AB244607

Anti-Lymphotactin/ATAC antibody [EPR20426-92] - BSA and Azide free (Capture)

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Rabbit Recombinant Monoclonal XCL1 antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

View Alternative Names

LTN, SCYC1, XCL1, Lymphotactin, ATAC, C motif chemokine 1, Cytokine SCM-1, Lymphotaxin, SCM-1-alpha, Small-inducible cytokine C1, XC chemokine ligand 1

1 Images
Sandwich ELISA - Anti-Lymphotactin/ATAC antibody [EPR20426-92] - BSA and Azide free (Capture) (AB244607)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-Lymphotactin/ATAC antibody [EPR20426-92] - BSA and Azide free (Capture) (AB244607)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab264620).

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR20426-92

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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Product details

ab244607 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human XCL1. The recommended pair for sandwich ELISA is:
Capture: ab244607, Human XCL1 Capture Antibody (unconjugated)
Detector: ab244857, Human XCL1 Detector Antibody (unconjugated)
The reference range value is 97.48 - 2800 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Lymphotactin also known as ATAC (Activation-induced T cell-derived and chemokine related cytokine) is a chemokine that plays an important role in immune system communication. It has a molecular mass of around 12 kDa. Lymphotactin is unique because it is the only member of the C class chemokines lacking one of the conserved cysteines found in other chemokines. It is primarily expressed in activated T cells and NK cells and can be found in tissues such as the spleen thymus and lymph nodes.
Biological function summary

This chemokine specifically attracts T cells and NK cells to sites of inflammation. It is not known to form part of larger molecular complexes. Lymphotactin contributes to cell signaling events that direct immune cells to infection sites or areas of tissue damage ensuring specific and effective immune responses. This targeting is especially useful during the immune system’s response to pathogens aiding in the clearance of infections.

Pathways

Lymphotactin influences immune response pathways especially those involved in cell-mediated responses. It interacts with the chemokine receptor XCR1 which plays a role in immune surveillance by guiding T cells to infected zones. Lymphotactin's activity bridges innate and adaptive immunity by directing cells where they are needed most linking it to pathways like cytokine signaling and inflammatory response.

Lymphotactin has a role in conditions such as inflammatory bowel disease and certain autoimmune disorders. Overproduction or dysregulation can exacerbate these conditions by leading to excessive immune cell infiltration and inflammation. The chemokine connects to proteins like XCR1 in these disease contexts influencing cellular migration and the extent of an inflammatory response. Understanding its disease-related interactions helps in the development of targeted therapies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
See full target information XCL1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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