Rabbit Recombinant Monoclonal LYPD3 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (AB246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img24070.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (AB246349)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (AB246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img113154.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (AB246349)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (AB246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137118.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (AB246349)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (AB246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138287.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (AB246349)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (AB246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img89402.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (AB246349)")
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2 - 7.4
Constituents: PBS- Form
Liquid
- Clonality
Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
5 products for Alternative Product
Target data
Function
Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
Alternative names
C4.4A, UNQ491/PRO1007, LYPD3, Ly6/PLAUR domain-containing protein 3, GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4
Recommended products
Rabbit Recombinant Monoclonal LYPD3 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2 - 7.4
Constituents: PBS- Form
Liquid
- Clonality
Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Carrier free
Yes
- Clone number
SP208
- Purification technique
Affinity purification Protein A/G
- Concentration
- Purification notes
Purified from TCS by protein A/G.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
+4°C
- Storage information
Do Not Freeze
Notes
ab246349 is the carrier-free version of Anti-LYPD3 antibody [SP208] ab183357.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.
This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LYPD3 also known as C4.4A is a glycosylphosphatidylinositol (GPI)-anchored protein with a molecular weight of approximately 40 kDa. It belongs to the Ly6/PLAUR domain family. This protein is mainly expressed in stratified epithelia and also found in some other tissues. LYPD3 shows higher expression levels in certain cancer cell types indicating its role in tumorigenesis.
- Biological function summary
LYPD3 functions in cellular adhesion and migration processes. It interacts with extracellular matrix components facilitating the movement and positioning of cells. It acts as a part of a protein complex that is important for cell communication and tissue organization. Its high expression in some cancer types suggests its involvement in processes that drive cancer progression including metastasis.
- Pathways
LYPD3 participates in key signaling cascades including integrin-mediated pathways. These pathways are important for mediating cell-matrix interactions and influence cell movement and survival. LYPD3 has known interactions with integrin proteins suggesting a collaborative role that modulates cell adhesion dynamics. These interactions make it an important player in cell migration and invasion processes that are pivotal for normal physiological events and pathological conditions.
- Associated diseases and disorders
LYPD3 shows significant involvement in cancers such as squamous cell carcinoma and prostate cancer. The protein aids the metastatic spread of these cancers by promoting cell migration and invasion. It has been associated with other proteins like laminin which supports cancer cell detachment and dissemination. Understanding LYPD3's role in cancer biology helps in identifying therapeutic targets for impeding cancer progression.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
10 product images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img24070.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human cervix carcinoma tissue sections labeling LYPD3 with Anti-LYPD3 antibody [SP208] ab183357 at 1/100 dilution (4.65 µg/ml). Heat mediated antigen retrieval was performed Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0, epitope retrieval solution 1) for 20 mins. Rabbit specific IHC polymer detection kit HRP/DAB (Rabbit specific IHC polymer detection kit HRP/DAB ab209101) was used as the secondary antibody. Negative control: PBS instead of the primary antibody. Hematoxylin was used as a counterstain.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-LYPD3 antibody [SP208] ab183357)![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img113154.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human skin tissue sections labeling LYPD3 with Anti-LYPD3 antibody [SP208] ab183357 at 1/100 dilution (4.65 µg/ml). Heat mediated antigen retrieval was performed Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0, epitope retrieval solution 1) for 20 mins. Rabbit specific IHC polymer detection kit HRP/DAB (Rabbit specific IHC polymer detection kit HRP/DAB ab209101) was used as the secondary antibody. Negative control: PBS instead of the primary antibody. Hematoxylin was used as a counterstain.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-LYPD3 antibody [SP208] ab183357)![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137118.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue labeling LYPD3 with Anti-LYPD3 antibody [SP208] ab183357 at 1/100 dilution.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-LYPD3 antibody [SP208] ab183357).
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138287.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin squamous cell carcinoma tissue labeling LYPD3 with Anti-LYPD3 antibody [SP208] ab183357 at 1/100 dilution.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-LYPD3 antibody [SP208] ab183357).
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img89402.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human esophagus tissue labeling LYPD3 with Anti-LYPD3 antibody [SP208] ab183357 at 1/100 dilution.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-LYPD3 antibody [SP208] ab183357).
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138038.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human bladder tissue labeling LYPD3 with Anti-LYPD3 antibody [SP208] ab183357 at 1/100 dilution.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-LYPD3 antibody [SP208] ab183357).
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138543.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human cervix tissue labeling LYPD3 with Anti-LYPD3 antibody [SP208] ab183357 at 1/100 dilution.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-LYPD3 antibody [SP208] ab183357).
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137677.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling LYPD3 with Anti-LYPD3 antibody [SP208] ab183357 at 1/100 dilution.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-LYPD3 antibody [SP208] ab183357).
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img49347.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human breast ductal cell carcinoma tissue labeling LYPD3 with Anti-LYPD3 antibody [SP208] ab183357 at 1/100 dilution.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-LYPD3 antibody [SP208] ab183357).
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img136714.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human cervical squamous cell carcinoma tissue labeling LYPD3 with Anti-LYPD3 antibody [SP208] ab183357 at 1/100 dilution.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-LYPD3 antibody [SP208] ab183357).
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138038.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138543.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137677.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img49347.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349), expandable thumbnail](https://content.abcam.com/products/images/lypd3-antibody-sp208-bsa-and-azide-free-ab246349--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img136714.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP208] - BSA and Azide free (ab246349)")
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com