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AB192845

Anti-LYPD3 antibody [SP250] - N-terminal

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(1 Review)

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Rabbit Recombinant Monoclonal LYPD3 antibody. N-terminal. Suitable for Flow Cyt, IHC-P and reacts with Human samples.

View Alternative Names

C4.4A, UNQ491/PRO1007, LYPD3, Ly6/PLAUR domain-containing protein 3, GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4

2 Images
Flow Cytometry - Anti-LYPD3 antibody [SP250] - N-terminal (AB192845)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-LYPD3 antibody [SP250] - N-terminal (AB192845)

Flow cytometric analysis of BxPC-3 (human pancreas adenocarcinoma cell line) cells labeling LYPD3 with ab192845 at 1/100 dilution (green) compared with a negative control rabbit IgG (blue).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP250] - N-terminal (AB192845)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD3 antibody [SP250] - N-terminal (AB192845)

Formalin-fixed paraffin-embedded human skin tissue stained for LYPD3 using ab192845 at 1/100 dilution in immunohistochemical analysis.

  • 578 PE

    PE Anti-LYPD3 antibody [SP250] (N-terminal)

  • 660 APC

    APC Anti-LYPD3 antibody [SP250] (N-terminal)

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-LYPD3 antibody [SP250] - N-terminal

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-LYPD3 antibody [SP250] - N-terminal

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-LYPD3 antibody [SP250] - N-terminal

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-LYPD3 antibody [SP250] - N-terminal

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-LYPD3 antibody [SP250] - N-terminal

  • Carrier free

    Anti-LYPD3 antibody [SP250] - BSA and Azide free

  • HRP

    HRP Anti-LYPD3 antibody [SP250] (N-terminal)

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-LYPD3 antibody [SP250] - N-terminal

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

SP250

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/100", "FlowCyt-species-notes": "<p>Incubate with primary antibody for 30 minutes at 4°C.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p>Boil tissue section in citrate buffer pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes.</p><p>Incubate with primary antibody for 10 minutes at room temperature</p>" }, "Mouse": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from TCS by Protein A/G.
Storage buffer
pH: 7.6 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LYPD3 also known as C4.4A is a glycosylphosphatidylinositol (GPI)-anchored protein with a molecular weight of approximately 40 kDa. It belongs to the Ly6/PLAUR domain family. This protein is mainly expressed in stratified epithelia and also found in some other tissues. LYPD3 shows higher expression levels in certain cancer cell types indicating its role in tumorigenesis.
Biological function summary

LYPD3 functions in cellular adhesion and migration processes. It interacts with extracellular matrix components facilitating the movement and positioning of cells. It acts as a part of a protein complex that is important for cell communication and tissue organization. Its high expression in some cancer types suggests its involvement in processes that drive cancer progression including metastasis.

Pathways

LYPD3 participates in key signaling cascades including integrin-mediated pathways. These pathways are important for mediating cell-matrix interactions and influence cell movement and survival. LYPD3 has known interactions with integrin proteins suggesting a collaborative role that modulates cell adhesion dynamics. These interactions make it an important player in cell migration and invasion processes that are pivotal for normal physiological events and pathological conditions.

LYPD3 shows significant involvement in cancers such as squamous cell carcinoma and prostate cancer. The protein aids the metastatic spread of these cancers by promoting cell migration and invasion. It has been associated with other proteins like laminin which supports cancer cell detachment and dissemination. Understanding LYPD3's role in cancer biology helps in identifying therapeutic targets for impeding cancer progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
See full target information LYPD3
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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