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AB201163

Anti-LYPD6B antibody

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(1 Review)

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(1 Publication)

Rabbit Polyclonal LYPD6B antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LYPD6B aa 1-150.

View Alternative Names

Ly6/PLAUR domain-containing protein 6B, LYPD6B

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD6B antibody (AB201163)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYPD6B antibody (AB201163)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human endometrial cancer tissue labeling LYPD6B with ab201163 at 1/100 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LYPD6B aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q8NI32

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LYPD6B also known as lymphocyte antigen 6 family member D6B is a protein that has mechanical roles in cellular processes particularly in relation with the regulation of signaling pathways. The protein has an approximate mass of 15 to 20 kDa. Expression of LYPD6B occurs in specific tissues including the brain and the immune system where its presence indicates involvement in cellular communication and other dynamic processes within these organs.
Biological function summary

Studies suggest that LYPD6B influences nicotinic acetylcholine receptor (nAChR) signaling. While not part of a large complex it acts independently or with select binding partners to modulate this receptor's function. It facilitates efficient neurotransmission which plays an important role in cognitive processes and other nervous system functions. Its role in immune tissues also suggests potential involvement in immune response modulation.

Pathways

LYPD6B participates in the cholinergic signaling pathway. This pathway connects with the overall functioning of the nervous system and influences neuroimmune communication. The protein interacts with other key proteins like acetylcholine receptor subunits which are essential for signal transduction. LYPD6B helps fine-tune receptor activity and influences the signal intensity and duration in these pathways.

LYPD6B appears linked to neurological disorders and autoimmune conditions. Altered LYPD6B function or expression could affect conditions such as Alzheimer's disease and myasthenia gravis. In Alzheimer’s its connection with the cholinergic pathway and receptor subunits could influence disease progression through impacts on neurotransmission. In myasthenia gravis a disorder affecting communication between nerves and muscles LYPD6B's modulation of receptor activity could alter disease symptoms or progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (PubMed : 26586467, PubMed : 34631692). In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner (PubMed : 26586467). Modulates specifically alpha-3(3) : beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2) : alpha-5 : beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence (PubMed : 26586467). However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs (PubMed : 34631692).
See full target information LYPD6B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 7: PubMed30084827

2018

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.

Applications

Unspecified application

Species

Unspecified reactive species

Melissa Kane,Stephanie V Rebensburg,Matthew A Takata,Trinity M Zang,Masahiro Yamashita,Mamuka Kvaratskhelia,Paul D Bieniasz
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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